Reactome Pathway Database

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PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Show undefined attributes

catalystActivity

[CatalystActivity:10965279] 4-aminobutyrate:2-oxoglutarate transaminase activity of PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

dbId 10965281

displayName PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

eventOf

[Pathway:R-DDI-916853] Degradation of GABA - Dictyostelium discoideum

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-DDI-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate - Dictyostelium discoideum

inferredFrom

[Reaction:R-HSA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
Conversion of GABA to Succinate Semialdehyde

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:170941] Dictyostelium discoideum

stId R-DDI-916855

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DDI-916853] Degradation of GABA

(precedingEvent)

[Reaction:R-DDI-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate

(inferredTo)

[Reaction:R-HSA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

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