Reactome Pathway Database

Schema > Reaction > Entries

2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 Show undefined attributes

category binding

compartment

created [InstanceEdit:10201029] Weiser, Joel, 2025年08月27日

dbId 10285084

displayName 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1

eventOf

[Pathway:R-CFA-8853659] RET signaling - Canis familiaris

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[BlackBoxEvent:R-CFA-8854981] SHC1 in the RET complex is phosphorylated - Canis familiaris

inferredFrom

[Reaction:R-HSA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

2x p-5Y-RET:GDNF:GFRA complexes bind SHC1

output

[Complex:R-CFA-8854400] 2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane]

precedingEvent

[Reaction:R-CFA-8853792] RET tyrosine phosphorylation - Canis familiaris

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49646] Canis familiaris

stId R-CFA-8853737

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CFA-8853659] RET signaling

(precedingEvent)

[BlackBoxEvent:R-CFA-8854981] SHC1 in the RET complex is phosphorylated

(inferredTo)

[Reaction:R-HSA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1

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