Reactome Pathway Database

Schema > Reaction > Entries

Binding of SHC1 to insulin receptor Show undefined attributes

category binding

compartment

created [InstanceEdit:10201029] Weiser, Joel, 2025年08月27日

dbId 10206263

displayName Binding of SHC1 to insulin receptor

eventOf

[Pathway:R-CFA-74751] Insulin receptor signalling cascade - Canis familiaris

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-CFA-74742] Phosphorylation of SHC1 - Canis familiaris

inferredFrom

[Reaction:R-HSA-74740] Binding of SHC1 to insulin receptor - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Binding of SHC1 to insulin receptor

output

[Complex:R-CFA-74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]

precedingEvent

[Reaction:R-CFA-74715] Autophosphorylation of insulin receptor - Canis familiaris

regulatedBy

[NegativeRegulation:10206008] Negative regulation by 'GRB10:INSR [plasma membrane]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49646] Canis familiaris

stId R-CFA-74740

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CFA-74751] Insulin receptor signalling cascade

(precedingEvent)

[Reaction:R-CFA-74742] Phosphorylation of SHC1

(inferredTo)

[Reaction:R-HSA-74740] Binding of SHC1 to insulin receptor

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