Reactome Pathway Database

Schema > Reaction > Entries

GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH Show undefined attributes

catalystActivity

[CatalystActivity:10274210] lactoylglutathione lyase activity of GLO1 dimer:2xZn2+ [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10201029] Weiser, Joel, 2025年08月27日

dbId 10274212

displayName GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

eventOf

[Pathway:R-CFA-70268] Pyruvate metabolism - Canis familiaris

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-CFA-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT - Canis familiaris

goBiologicalProcess [GO_BiologicalProcess:8712] methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

inferredFrom

[Reaction:R-HSA-5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH
GLO1 dimer:2xZn2+ trnasforms glutathione and methylglyoxal to lactoylglutathione

output

[SimpleEntity:R-ALL-5694130] (R)-S-LGSH [cytosol]

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49646] Canis familiaris

stId R-CFA-5694071

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CFA-70268] Pyruvate metabolism

(precedingEvent)

[Reaction:R-CFA-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT

(inferredTo)

[Reaction:R-HSA-5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

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