Reactome Pathway Database

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SHC1 events in EGFR signaling Show undefined attributes

created [InstanceEdit:10201029] Weiser, Joel, 2025年08月27日

dbId 10306602

displayName SHC1 events in EGFR signaling

eventOf

[Pathway:R-CFA-177929] Signaling by EGFR - Canis familiaris

evidenceType [EvidenceType:9965817] inferred by electronic annotation

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-CFA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Canis familiaris
[Reaction:R-CFA-177933] SHC1 phosphorylation by phosphorylated EGFR - Canis familiaris
[Reaction:R-CFA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Canis familiaris
[Reaction:R-CFA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Canis familiaris

inferredFrom

[Pathway:R-HSA-180336] SHC1 events in EGFR signaling - Homo sapiens

isInDisease false

isInferred true

maxDepth 2

name

SHC1 events in EGFR signaling

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:49646] Canis familiaris

stId R-CFA-180336

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CFA-177929] Signaling by EGFR

(inferredTo)

[Pathway:R-HSA-180336] SHC1 events in EGFR signaling

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