Reactome Pathway Database

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TXNRD2 catalyzes the reduction of TXN2 by NADPH Show undefined attributes

catalystActivity

[CatalystActivity:10913433] thioredoxin-disulfide reductase (NADPH) activity of TXNRD2 dimer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

dbId 10913435

displayName TXNRD2 catalyzes the reduction of TXN2 by NADPH

eventOf

[Pathway:R-CEL-3299685] Detoxification of Reactive Oxygen Species - Caenorhabditis elegans

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-CEL-3322995] PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O - Caenorhabditis elegans

inferredFrom

[Reaction:R-HSA-3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

TXNRD2 catalyzes the reduction of TXN2 by NADPH

output

precedingEvent

[Reaction:R-CEL-3322995] PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O - Caenorhabditis elegans

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68320] Caenorhabditis elegans

stId R-CEL-3323050

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CEL-3299685] Detoxification of Reactive Oxygen Species

(precedingEvent)

[Reaction:R-CEL-3322995] PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

(inferredTo)

[Reaction:R-HSA-3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH

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