Reactome Pathway Database

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CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation Show undefined attributes

catalystActivity

[CatalystActivity:10883480] monooxygenase activity of Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

dbId 10883482

displayName CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

eventOf

[Pathway:R-CEL-211981] Xenobiotics - Caenorhabditis elegans

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-212004] CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68320] Caenorhabditis elegans

stId R-CEL-212004

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CEL-211981] Xenobiotics

(inferredTo)

[Reaction:R-HSA-212004] CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

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