Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

botE HC disulfide bonded [synaptic vesicle membrane] Show undefined attributes

compartment

[Compartment:201753] synaptic vesicle membrane

componentOf

[Complex:R-CBO-5228951] BoNT/E HC:LC dimer [synaptic vesicle membrane] - Clostridium botulinum

created [InstanceEdit:181561] Gopinathrao, G, 2006年06月14日 16:40:11

crossReference

[DatabaseIdentifier:11944965] Mondo:0005498

dbId 181575

deleted

disease

[Disease:3632909] botulism

displayName botE HC disulfide bonded [synaptic vesicle membrane]

endCoordinate 1251

goCellularComponent [GO_CellularComponent:2454709] host cell endocytic vesicle membrane

hasModifiedResidue

[InterChainCrosslinkedResidue:5228672] Inter-chain Crosslink via L-cystine (cross-link) at 426 and 412

inDisease true

literatureReference

[LiteratureReference:5228677] Botulinum neurotoxin type E fragmented with endoproteinase Lys-C reveals the site trypsin nicks and homology with tetanus neurotoxin

maxDepth 1

modified [InstanceEdit:9963749] Weiser, Joel, 2025年08月15日

name

botE HC disulfide bonded
BoNT/E HC disulfide bonded
BoNT Heavy chain Type E

referenceEntity [ReferenceGeneProduct:uniprot:Q00496] UniProt:Q00496 botE

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:168825] Clostridium botulinum

stId R-CBO-181575

startCoordinate 423

updateTrackers

Referrals

(updatedInstance)

(replacementInstances)

(activeUnit)

(hasComponent)

[Complex:R-CBO-5228951] BoNT/E HC:LC dimer [synaptic vesicle membrane]

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