Reactome Pathway Database

Schema > Reaction > Entries

AKR1C1 hydrogenates PREDN,PREDL Show undefined attributes

catalystActivity

[CatalystActivity:10414879] steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of AKR1C1 [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10414881

displayName AKR1C1 hydrogenates PREDN,PREDL

eventOf

[Pathway:R-BTA-9757110] Prednisone ADME - Bos taurus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-BTA-9758661] UGT2B7,2B17,1A3 glucuronidates PRED metabolites - Bos taurus

inferredFrom

[Reaction:R-HSA-9758682] AKR1C1 hydrogenates PREDN,PREDL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

AKR1C1 hydrogenates PREDN,PREDL

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48898] Bos taurus

stId R-BTA-9758682

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-BTA-9757110] Prednisone ADME

(precedingEvent)

[Reaction:R-BTA-9758661] UGT2B7,2B17,1A3 glucuronidates PRED metabolites

(inferredTo)

[Reaction:R-HSA-9758682] AKR1C1 hydrogenates PREDN,PREDL

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