Reactome Pathway Database

Schema > Reaction > Entries

IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments Show undefined attributes

category binding

compartment

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10349421

displayName IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

eventOf

[Pathway:R-BTA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Bos taurus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[BlackBoxEvent:R-BTA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Bos taurus

inferredFrom

[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

output

[Complex:R-BTA-975137] p-IRAK2:oligo-TRAF6 [endosome membrane]

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48898] Bos taurus

stId R-BTA-975185

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-BTA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

(precedingEvent)

[BlackBoxEvent:R-BTA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane

(inferredTo)

[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

© 2025 Reactome

Cite Us!