Reactome Pathway Database

Schema > Reaction > Entries

TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 Show undefined attributes

catalystActivity

[CatalystActivity:10386193] K63-linked deubiquitinase activity of TNFAIP3:K63polyUb-RIPK1 [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10386195

displayName TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1

eventOf

[Pathway:R-BTA-5689896] Ovarian tumor domain proteases - Bos taurus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-BTA-5690827] TNFAIP3 (A20) ubiquitinates RIPK1 - Bos taurus

inferredFrom

[Reaction:R-HSA-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48898] Bos taurus

stId R-BTA-5690856

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-BTA-5689896] Ovarian tumor domain proteases

(precedingEvent)

[Reaction:R-BTA-5690827] TNFAIP3 (A20) ubiquitinates RIPK1

(inferredTo)

[Reaction:R-HSA-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1

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