Reactome Pathway Database

Schema > BlackBoxEvent > Entries

BIRC(cIAP1/2) ubiquitinates RIPK1 Show undefined attributes

catalystActivity

[CatalystActivity:10377405] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]

category omitted

compartment

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10377407

displayName BIRC(cIAP1/2) ubiquitinates RIPK1

eventOf

[Pathway:R-BTA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Bos taurus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

BIRC(cIAP1/2) ubiquitinates RIPK1

output

[Complex:R-BTA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]

precedingEvent

[Reaction:R-BTA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Bos taurus

releaseDate 2025年09月18日

schemaClass BlackBoxEvent

species

[Species:48898] Bos taurus

stId R-BTA-5357757

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-BTA-5357956] TNFR1-induced NF-kappa-B signaling pathway

(precedingEvent)

(inferredTo)

[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1

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