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Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA Show undefined attributes

catalystActivity

[CatalystActivity:10326020] alpha-methylacyl-CoA racemase activity of AMACR [peroxisomal matrix]

category transition

compartment

[Compartment:17951] peroxisomal matrix

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10326506

displayName Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

eventOf

[Pathway:R-BTA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Bos taurus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-BTA-193455] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA - Bos taurus

inferredFrom

[Reaction:R-HSA-193763] Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA - Homo sapiens

input

[SimpleEntity:R-ALL-193793] 25(R) TetraHCA-CoA [peroxisomal matrix]

isInDisease false

isInferred true

maxDepth 1

name

Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
25(R) TetraHCA-CoA => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

output

[SimpleEntity:R-ALL-193422] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA [peroxisomal matrix]

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48898] Bos taurus

stId R-BTA-193763

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-BTA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol

(precedingEvent)

[Reaction:R-BTA-193455] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA

(inferredTo)

[Reaction:R-HSA-193763] Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

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