Reactome Pathway Database

Schema > Reaction > Entries

CYP46A1 24-hydroxylates CHOL Show undefined attributes

catalystActivity

[CatalystActivity:10326027] cholesterol 24-hydroxylase activity of CYP46A1 [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10326029

displayName CYP46A1 24-hydroxylates CHOL

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-192061] CYP46A1 24-hydroxylates CHOL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP46A1 24-hydroxylates CHOL
cholesterol + O2 + reduced (NADPH--hemoprotein reductase) => (24S)-hydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48898] Bos taurus

stId R-BTA-192061

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(inferredTo)

[Reaction:R-HSA-192061] CYP46A1 24-hydroxylates CHOL

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