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gain_of_function of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane] Show undefined attributes

created [InstanceEdit:9665888] Orlic-Milacic, Marija, 2019年11月01日

dbId 9665873

diseaseEntity [Complex:R-HSA-9665882] p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane]

displayName gain_of_function of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane]

functionalStatus

[FunctionalStatus:2362351] gain_of_function via non_conservative_missense_variant

normalEntity [Complex:R-HSA-1250194] p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]

schemaClass EntityFunctionalStatus

Referrals

(entityFunctionalStatus)

[Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1

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