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gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane] Show undefined attributes

created [InstanceEdit:9665434] Orlic-Milacic, Marija, 2019年10月30日

dbId 9665440

diseaseEntity [Complex:R-HSA-9665441] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane]

displayName gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane]

functionalStatus

[FunctionalStatus:2362351] gain_of_function via non_conservative_missense_variant

normalEntity [Complex:R-HSA-1250194] p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]

schemaClass EntityFunctionalStatus

Referrals

(entityFunctionalStatus)

[Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1

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