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9622838
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Intracellular proteins are targeted for proteolytic degradat...
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Summation
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Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (Hspa8) acts as the constitutive chaperone that binds a KFERQ-domain containing substrate in the cytosol. Consequently, the substrate:Hspa8 complex translocates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (Lamp2). Post-binding, Hspa8 is released from the complex to allow multimerization of Lamp2 and internalization of the substrate (Bandyopadhyay U et al. 2008).