Reactome Pathway Database

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Binding of Gab2 to tyrosine phosphorylated Shc promotes the ... Show undefined attributes

created [InstanceEdit:912521] Jupe, S, 2010年07月09日

dbId 912524

displayName Binding of Gab2 to tyrosine phosphorylated Shc promotes the ...

literatureReference

[LiteratureReference:507990] Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a
[LiteratureReference:508013] Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
[LiteratureReference:507926] New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

modified [InstanceEdit:975849] Jupe, S, 2010年10月05日

schemaClass Summation

text Binding of Gab2 to tyrosine phosphorylated Shc promotes the phosphorylation of Gab2 by an unknown kinase. Gab2 becomes tyrosine phosphorylated in response to IL-2 (Brockdorff et al. 2001) and IL-3 (Gu et al. 1998). Chimeric receptors were used to demonstrate that Shc is sufficient for Gab2 tyrosine phosphorylation. In response to IL-3, Grb2 was also required, reflecting that Gab2 is recruited to the activated cytokine receptor complex as a complex of Gab2:Grb2 (Gu et al. 2000).

Referrals

(summation)

[BlackBoxEvent:R-HSA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2

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