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9020507
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Based on study in rats, MECP2 binds to methylated GRIN2B (NR...
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Based on study in rats, MECP2 binds to methylated GRIN2B (NR2B) gene promoter, encoding glutamate (NMDA) receptor subunit epsilon-2. Methylation of the GRIN2B promoter and the subsequent MECP2 binding is promoted by increased neuronal activity and suppressed by low neuronal activity (Lee et al. 2008).