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RET can bind FRS2, via phosphotyrosine-1062 (p-Y1062) (Kurokawa et al. 2001, Meillo et al. 2001). FRS2 competes with SHC1 for p-Y1062 binding (Lundgren et al. 2006). RET has been reported to associate with FRS2, instead of SHC1, when associated with lipid rafts (Paratcha et al. 2001).