dbId
6808488
displayName
ALDH1L2 (mitochondrial 10-formyltetrahydrofolate dehydrogena...
schemaClass
Summation
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ALDH1L2 (mitochondrial 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of mitochondrial biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).