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6803891
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SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding o...
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Summation
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SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding of SFN to BAX prevents BAX translocation from cytosol to mitochondria, thus inhibiting cytochrome C release and apoptosis. SFN therefore promotes G2 cell cycle arrest while simultaneously preventing apoptosis (Samuel et al. 2001).