dbId
193838
displayName
Sterol 12alpha hydroxylase (CYP8B1), associated with the end...
schemaClass
Summation
text
Sterol 12alpha hydroxylase (CYP8B1), associated with the endoplasmic reticulum membrane, catalyses the 12-alpha-hydroxylation of 4-Cholesten-7alpha,27-diol-3-one (4CHOL7a,27DONE) to 4-Cholesten-7alpha,12alpha,27-triol-3-one. While the human gene has been cloned (Gafvels et al. 1999), its protein product has not been characterised, and the enzymatic properties of human CYP8B1 protein are inferred from those of its well-characterised rabbit homolog (Ishida et al. 1992).
These papers support Reaction:192157 "CYP8B1 12-hydroxylates 4CHOL7aOLONE" but not this one, so this reaction has been set to _doRelease = false.