Phosphorylated STAT92E dissociates from HOP and DOME and dimerises

Stable Identifier
R-DME-209321
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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Drosophila signaling pathways (Drosophila melanogaster)
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After STAT92E is phosphorylated, it dissociates from phosphorylated HOP and phosphorylated DOME or the receptor complex. The now free phosphorylated STAT92E forms a dimer with another phosphorylated STAT92E molecule. These dimers are stabilised by the interaction between the SH2 domain of one molecule and the phospho Tyr of the other.
Literature References
PubMed ID Title Journal Year
9671298 Three-dimensional structure of the Stat3beta homodimer bound to DNA

Becker, S, Groner, B, Muller, CW

Nature 1998
16129580 Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E

Karsten, P, Plischke, I, Perrimon, N, Zeidler, MP

Cell Signal 2006
10823841 Constitutive activation of STAT5 by a point mutation in the SH2 domain

Ariyoshi, K, Nosaka, T, Yamada, K, Onishi, M, Oka, Y, Miyajima, A, Kitamura, T

J Biol Chem 2000
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