Reactome Pathway Database

hydroperoxy fatty acid [extracellular region]

Stable Identifier

R-ALL-2173764

Type

Chemical Compound [SimpleEntity]

Compartment

extracellular region

Locations in the PathwayBrowser

for Species:

Expand all

Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - Toll-like Receptor Cascades (Bos taurus)
    - Regulation of TLR by endogenous ligand (Bos taurus)
      - oxLDL:CD36 binds TLR4:TLR6 (Bos taurus)
        
        TLR4:TLR6:CD36:oxLDL [plasma membrane] (Bos taurus)
        
        oxLDL:CD36 [plasma membrane] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]
        
        oxLDL:CD36 [plasma membrane] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]

Vesicle-mediated transport (Bos taurus)

- Binding and Uptake of Ligands by Scavenger Receptors (Bos taurus)
  - Scavenging by Class A Receptors (Bos taurus)
    - COLEC12 (SCARA4) binds ligands (Bos taurus)
      - COLEC12:Ligand [plasma membrane] (Bos taurus)
        
        Ligands of COLEC12 [extracellular region] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]
      - Ligands of COLEC12 [extracellular region] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]
    - COLEC12:ligand is endocytosed (Bos taurus)
      - COLEC12:Ligand [plasma membrane] (Bos taurus)
        
        Ligands of COLEC12 [extracellular region] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class B Receptors (Bos taurus)
    - Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Bos taurus)
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Bos taurus)
        
        Ligands of CD36 [extracellular region] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1 (SR-BI, CLA-1) binds ligands (Bos taurus)
      - Ligands of SCARB1 [extracellular region] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARB1:Ligand [plasma membrane] (Bos taurus)
        
        Ligands of SCARB1 [extracellular region] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1:ligand is endocytosed (Bos taurus)
      - SCARB1:Endocytosed Ligand [plasma membrane] (Bos taurus)
        
        Endocytosed Ligands of SCARB1 [extracellular region] (Bos taurus)
        
        oxidized LDL [extracellular region] (Bos taurus)
        
        hydroperoxy fatty acid [extracellular region]

Vesicle-mediated transport (Canis familiaris)

- Binding and Uptake of Ligands by Scavenger Receptors (Canis familiaris)
  - Scavenging by Class A Receptors (Canis familiaris)
    - MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)
      - MSR1:Ligand [plasma membrane] (Canis familiaris)
        
        Ligands of MSR1 [extracellular region] (Canis familiaris)
        
        oxidized LDL [extracellular region] (Canis familiaris)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class B Receptors (Canis familiaris)
    - Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Canis familiaris)
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Canis familiaris)
        
        Ligands of CD36 [extracellular region] (Canis familiaris)
        
        oxidized LDL [extracellular region] (Canis familiaris)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1 (SR-BI, CLA-1) binds ligands (Canis familiaris)
      - Ligands of SCARB1 [extracellular region] (Canis familiaris)
        
        oxidized LDL [extracellular region] (Canis familiaris)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARB1:Ligand [plasma membrane] (Canis familiaris)
        
        Ligands of SCARB1 [extracellular region] (Canis familiaris)
        
        oxidized LDL [extracellular region] (Canis familiaris)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1:ligand is endocytosed (Canis familiaris)
      - SCARB1:Endocytosed Ligand [plasma membrane] (Canis familiaris)
        
        Endocytosed Ligands of SCARB1 [extracellular region] (Canis familiaris)
        
        oxidized LDL [extracellular region] (Canis familiaris)
        
        hydroperoxy fatty acid [extracellular region]

Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Toll-like Receptor Cascades (Gallus gallus)
    - Regulation of TLR by endogenous ligand (Gallus gallus)
      - oxLDL:CD36 binds TLR4:TLR6 (Gallus gallus)
        
        TLR4:TLR6:CD36:oxLDL [plasma membrane] (Gallus gallus)
        
        oxLDL:CD36 [plasma membrane] (Gallus gallus)
        
        oxidized LDL [extracellular region] (Gallus gallus)
        
        hydroperoxy fatty acid [extracellular region]
        
        oxLDL:CD36 [plasma membrane] (Gallus gallus)
        
        oxidized LDL [extracellular region] (Gallus gallus)
        
        hydroperoxy fatty acid [extracellular region]

Vesicle-mediated transport (Gallus gallus)

- Binding and Uptake of Ligands by Scavenger Receptors (Gallus gallus)
  - Scavenging by Class A Receptors (Gallus gallus)
    - MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Gallus gallus)
      - MSR1:Ligand [plasma membrane] (Gallus gallus)
        
        Ligands of MSR1 [extracellular region] (Gallus gallus)
        
        oxidized LDL [extracellular region] (Gallus gallus)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class B Receptors (Gallus gallus)
    - Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Gallus gallus)
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Gallus gallus)
        
        Ligands of CD36 [extracellular region] (Gallus gallus)
        
        oxidized LDL [extracellular region] (Gallus gallus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1 (SR-BI, CLA-1) binds ligands (Gallus gallus)
      - Ligands of SCARB1 [extracellular region] (Gallus gallus)
        
        oxidized LDL [extracellular region] (Gallus gallus)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARB1:Ligand [plasma membrane] (Gallus gallus)
        
        Ligands of SCARB1 [extracellular region] (Gallus gallus)
        
        oxidized LDL [extracellular region] (Gallus gallus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1:ligand is endocytosed (Gallus gallus)
      - SCARB1:Endocytosed Ligand [plasma membrane] (Gallus gallus)
        
        Endocytosed Ligands of SCARB1 [extracellular region] (Gallus gallus)
        
        oxidized LDL [extracellular region] (Gallus gallus)
        
        hydroperoxy fatty acid [extracellular region]

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Regulation of TLR by endogenous ligand (Homo sapiens)
      - oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)
        
        TLR4:TLR6:CD36:oxLDL [plasma membrane] (Homo sapiens)
        
        oxLDL:CD36 [plasma membrane] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
        
        oxLDL:CD36 [plasma membrane] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging by Class A Receptors (Homo sapiens)
    - COLEC12 (SCARA4) binds ligands (Homo sapiens)
      - COLEC12:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of COLEC12 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
      - Ligands of COLEC12 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
    - COLEC12:ligand is endocytosed (Homo sapiens)
      - COLEC12:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of COLEC12 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
    - MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)
      - Ligands of MSR1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
      - MSR1:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of MSR1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
    - MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)
      - MSR1:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of MSR1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class B Receptors (Homo sapiens)
    - Platelet glycoprotein IV (CD36) binds ligands (Homo sapiens)
      - Ligands of CD36 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of CD36 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
    - Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of CD36 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)
      - Ligands of SCARB1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARB1:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of SCARB1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1:ligand is endocytosed (Homo sapiens)
      - SCARB1:Endocytosed Ligand [plasma membrane] (Homo sapiens)
        
        Endocytosed Ligands of SCARB1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class F Receptors (Homo sapiens)
    - SCARF1 (SREC-I) binds ligands (Homo sapiens)
      - Ligands of SCARF1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARF1:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of SCARF1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARF1:ligand is endocytosed (Homo sapiens)
      - SCARF1:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of SCARF1 [extracellular region] (Homo sapiens)
        
        oxidized LDL [extracellular region] (Homo sapiens)
        
        hydroperoxy fatty acid [extracellular region]

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Regulation of TLR by endogenous ligand (Mus musculus)
      - oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)
        
        TLR4:TLR6:CD36:oxLDL [plasma membrane] (Mus musculus)
        
        oxLDL:CD36 [plasma membrane] (Mus musculus)
        
        oxidized LDL [extracellular region] (Mus musculus)
        
        hydroperoxy fatty acid [extracellular region]
        
        oxLDL:CD36 [plasma membrane] (Mus musculus)
        
        oxidized LDL [extracellular region] (Mus musculus)
        
        hydroperoxy fatty acid [extracellular region]

Vesicle-mediated transport (Mus musculus)

- Binding and Uptake of Ligands by Scavenger Receptors (Mus musculus)
  - Scavenging by Class A Receptors (Mus musculus)
    - MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)
      - MSR1:Ligand [plasma membrane] (Mus musculus)
        
        Ligands of MSR1 [extracellular region] (Mus musculus)
        
        oxidized LDL [extracellular region] (Mus musculus)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class B Receptors (Mus musculus)
    - Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Mus musculus)
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Mus musculus)
        
        Ligands of CD36 [extracellular region] (Mus musculus)
        
        oxidized LDL [extracellular region] (Mus musculus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)
      - Ligands of SCARB1 [extracellular region] (Mus musculus)
        
        oxidized LDL [extracellular region] (Mus musculus)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARB1:Ligand [plasma membrane] (Mus musculus)
        
        Ligands of SCARB1 [extracellular region] (Mus musculus)
        
        oxidized LDL [extracellular region] (Mus musculus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1:ligand is endocytosed (Mus musculus)
      - SCARB1:Endocytosed Ligand [plasma membrane] (Mus musculus)
        
        Endocytosed Ligands of SCARB1 [extracellular region] (Mus musculus)
        
        oxidized LDL [extracellular region] (Mus musculus)
        
        hydroperoxy fatty acid [extracellular region]

Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Regulation of TLR by endogenous ligand (Rattus norvegicus)
      - oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)
        
        TLR4:TLR6:CD36:oxLDL [plasma membrane] (Rattus norvegicus)
        
        oxLDL:CD36 [plasma membrane] (Rattus norvegicus)
        
        oxidized LDL [extracellular region] (Rattus norvegicus)
        
        hydroperoxy fatty acid [extracellular region]
        
        oxLDL:CD36 [plasma membrane] (Rattus norvegicus)
        
        oxidized LDL [extracellular region] (Rattus norvegicus)
        
        hydroperoxy fatty acid [extracellular region]

Vesicle-mediated transport (Rattus norvegicus)

- Binding and Uptake of Ligands by Scavenger Receptors (Rattus norvegicus)
  - Scavenging by Class A Receptors (Rattus norvegicus)
    - MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Rattus norvegicus)
      - MSR1:Ligand [plasma membrane] (Rattus norvegicus)
        
        Ligands of MSR1 [extracellular region] (Rattus norvegicus)
        
        oxidized LDL [extracellular region] (Rattus norvegicus)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class B Receptors (Rattus norvegicus)
    - Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Rattus norvegicus)
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Rattus norvegicus)
        
        Ligands of CD36 [extracellular region] (Rattus norvegicus)
        
        oxidized LDL [extracellular region] (Rattus norvegicus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1 (SR-BI, CLA-1) binds ligands (Rattus norvegicus)
      - Ligands of SCARB1 [extracellular region] (Rattus norvegicus)
        
        oxidized LDL [extracellular region] (Rattus norvegicus)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARB1:Ligand [plasma membrane] (Rattus norvegicus)
        
        Ligands of SCARB1 [extracellular region] (Rattus norvegicus)
        
        oxidized LDL [extracellular region] (Rattus norvegicus)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1:ligand is endocytosed (Rattus norvegicus)
      - SCARB1:Endocytosed Ligand [plasma membrane] (Rattus norvegicus)
        
        Endocytosed Ligands of SCARB1 [extracellular region] (Rattus norvegicus)
        
        oxidized LDL [extracellular region] (Rattus norvegicus)
        
        hydroperoxy fatty acid [extracellular region]

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Regulation of TLR by endogenous ligand (Sus scrofa)
      - oxLDL:CD36 binds TLR4:TLR6 (Sus scrofa)
        
        TLR4:TLR6:CD36:oxLDL [plasma membrane] (Sus scrofa)
        
        oxLDL:CD36 [plasma membrane] (Sus scrofa)
        
        oxidized LDL [extracellular region] (Sus scrofa)
        
        hydroperoxy fatty acid [extracellular region]
        
        oxLDL:CD36 [plasma membrane] (Sus scrofa)
        
        oxidized LDL [extracellular region] (Sus scrofa)
        
        hydroperoxy fatty acid [extracellular region]

Vesicle-mediated transport (Sus scrofa)

- Binding and Uptake of Ligands by Scavenger Receptors (Sus scrofa)
  - Scavenging by Class A Receptors (Sus scrofa)
    - MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)
      - MSR1:Ligand [plasma membrane] (Sus scrofa)
        
        Ligands of MSR1 [extracellular region] (Sus scrofa)
        
        oxidized LDL [extracellular region] (Sus scrofa)
        
        hydroperoxy fatty acid [extracellular region]
  - Scavenging by Class B Receptors (Sus scrofa)
    - Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)
      - Platelet glycoprotein IV:Ligand [plasma membrane] (Sus scrofa)
        
        Ligands of CD36 [extracellular region] (Sus scrofa)
        
        oxidized LDL [extracellular region] (Sus scrofa)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1 (SR-BI, CLA-1) binds ligands (Sus scrofa)
      - Ligands of SCARB1 [extracellular region] (Sus scrofa)
        
        oxidized LDL [extracellular region] (Sus scrofa)
        
        hydroperoxy fatty acid [extracellular region]
      - SCARB1:Ligand [plasma membrane] (Sus scrofa)
        
        Ligands of SCARB1 [extracellular region] (Sus scrofa)
        
        oxidized LDL [extracellular region] (Sus scrofa)
        
        hydroperoxy fatty acid [extracellular region]
    - SCARB1:ligand is endocytosed (Sus scrofa)
      - SCARB1:Endocytosed Ligand [plasma membrane] (Sus scrofa)
        
        Endocytosed Ligands of SCARB1 [extracellular region] (Sus scrofa)
        
        oxidized LDL [extracellular region] (Sus scrofa)
        
        hydroperoxy fatty acid [extracellular region]

External Reference Information

External Reference

hydroperoxy fatty acid [ChEBI:64009]

Participates

as a component of

Other forms of this molecule

hydroperoxy fatty acid [endocytic vesicle lumen]

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