Division of Biological Sciences
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Collective Escape Dynamics and Leadership in Group-living Animals
Jadhav, VivekGroup-living organisms across taxa coordinate their movement to evade threats or predators. However, how information about threats, often available only to a few individuals within the group, efficiently propagates among ... -
From Diet to Fitness: Nutritional Ecology of Behaviour, Physiology, and Life-History in Indian Spiny-Tailed Lizards
Joshi, Mihir MakarandAnimals must consume nutrients in optimal amounts and ratios to maximize their fitness. However, most animals face various constraints to foraging optimally in their natural habitats. While studies conducted in the lab and ... -
A Functional Insights into Beadex: A Novel Regulator of Phagocytosis and Immune Signalling in Drosophila melanogaster
Jain, SakshiTranscription factors regulate development by controlling spatial and temporal gene expression, and their dysregulation is linked to malignancies such as leukemia. The LIM-domain only (LMO) family of transcriptional ... -
Mechanism of chloroquine-mediated suppression of drug tolerance in Mycobacterium tuberculosis
Guha, MadhuraAdjunctive host-directed therapies (HDTs) offer a promising approach to enhance tuberculosis (TB) treatment by shortening therapy and reducing lung damage. We previously demonstrated that chloroquine (CQ), an antimalarial ... -
Investigating the Immunoregulatory Role of Activin in the Modulation of Ferroptosis and Apoptosis During Mycobacterium tuberculosis Infection
Bijewar, Ashish SatishMycobacterium tuberculosis (Mtb), the etiological agent for tuberculosis (TB), is a leading cause of mortality, resulting from a single infectious pathogen. TB is one of the oldest diseases known to humankind. The evolutionary ... -
Investigating the role of RNA granule-associated proteins in stress response
Tiwari, SwetaCells continuously encounter environmental and chemical stresses that necessitate rapid and coordinated adaptive responses. While transcriptional regulation has long been considered the dominant mechanism governing stress ... -
Elucidating the conserved role of IPK2 kinases in inositol pyrophosphate metabolism and heat stress acclimation in land plants
Yadav, RanjanaInositol pyrophosphates (PP-InsPs) are soluble cellular messengers that integrate environmental cues to induce adaptive responses in eukaryotes. In plants, the biological functions of various PP-InsP species are poorly ... -
Cryo-EM Reveals Stepwise Assembly of Staphylococcus aureus Pore-forming Toxins in the Native Environment
Chatterjee, ArnabStaphylococcus aureus is an opportunistic, deadly pathogen that is Gram-positive and spherical. It asymptomatically colonizes 20% to 30% of the human population. The primary niche is the nasopharynx region of our body. ... -
A ribosomal protein that can influence morphogenesis in Dictyostelium discoideum and Saccharomyces cerevisiae
Amarnath, SmitaIn Dictyostelium discoideum, the decision to form a spore or a stalk cell can be influenced by the genotype, pre-aggregation phenotypic differences between cells, and intracellular interactions. Three sources of pre-aggregation ... -
A mouse model for dynamic mutation & fragile X Syndrome
Baskaran, SujathaThe major theme of our laboratory is to understand the phenomenon of "genomic imprinting". Broadly, genomic imprinting can be described as a process in which a particular gene or a set of genes shows differential expression ... -
Novel regulators of Drosophila melanogaster immune system
Chatterjee, ArunitaInnate immunity is the first line of defense in all immunocompetent organisms. Being devoid of the adaptive arm of immunity, Drosophila melanogaster serves as an excellent genetic model to understand the intricacies of ... -
Studies on catabolite repression and mRNA degradation in the bgl operon of Escherichia coli
Gulati, AbhilashaCarbon Catabolite Repression (CCR), the phenomenon by which bacteria alter gene expression in response to changes in nutritional availability, is operative in both Gram-positive and Gram-negative bacteria. This universal ... -
Resurrection of omega : The smallest subunit of bacterial RNApolymerase
Sarkar, ParamitaThe bacterial RNA polymerase (RNAP) holoenzyme is a multi-subunit complex that performs the essential function of gene transcription. While extensive information is available on the contribution of various subunits ?, ?’, ... -
Spectroscopic studies on conformation and interaction of a channel forming cyclohexapeptide and a few selected neuropeptides
Ramesh, JagannathanThe knowledge of the structure and conformation of biomolecules such as peptides, proteins, and nucleic acids is vital for understanding their function. The techniques used for analysis, both in solid and solution state, ... -
Biophysical characterization of interaction of SecB with theMBP and preMBP : IN VITRO studies
Beena, KProtein export is an essential cellular process in the functioning of any cell. In the case of E. coli, nearly 10-50% of proteins synthesized in the cytoplasm need to be exported across the membrane to their site of action, ... -
Protein-DNA interactions: a computer modelling study
Gopalakrishnan, BIn this chapter, interaction energy calculations between DNA and model polypeptides, viz., (Ala)<sub>20</sub>, (Ala-Val), and (Ser)<sub>20</sub>, indicate the following results: (i) When both the ?-helix and the DNA are ... -
Unfolding of Thymidylate synthase studies of wild type enzyme and engineered disulfide mutants
Agarwalla, SanjayProtein stability and folding are two related and important problems of present-day biochemistry. Enhancing the stability of naturally occurring proteins has widespread applications. The task appears feasible because of ... -
X-Ray studies on the aggregation of aminoacids and peptides in the solid state
Suresh, C GThis thesis is concerned with the study of characteristic aggregation patterns of amino acids and peptides, and their possible relevance to chemical evolution. A careful examination, reported in Chapter 1, of the crystal ... -
Conformational studies on globular proteins : data analysis
Srinivasan, NThe present analysis on glycyl residues in proteins, as examined both from conformational angles as well as their locations in different secondary structural regions, brings out a number of observable features. Some of the ... -
Conformational studies on beta-lactam antibiotics
Vasudevan,T KThe present conformational analyses on ?-lactam compounds have brought out many important factors that contribute to a better understanding of antibiotic-receptor interactions and to the design of better drugs. The studies ...