The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
Primary immunodeficiency (PI) doesn’t have to feel isolating.
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Even if you’re new to PI advocacy, there are many ways to raise awareness. We’ll help you get started.
Our resources, services, and outreach are largely funded by donors like you.
Your gift of time makes a difference. IDF always needs peer support participants and event volunteers.
Whether you join the IDF Sustainers Club or start a Facebook fundraiser, all efforts can make a difference.
Take our self-assessment to find out if your symptoms could point to a primary immunodeficiency (PI). It’s an informative way to gather insights that you can discuss with your healthcare provider.
Join us for a transformative experience where every story, voice, and journey creates something extraordinary.
A mosaic showcases the beauty of diversity and strength that arises from unique pieces coming together.
For this reason, the 2026 National Conference in San Antonio, TX features a mosaic theme, and this vibrant, dynamic event will blend individual primary immunodeficiency (PI) stories to form a unique whole.
Make a difference this year! Our 2025 season offers multiple ways to get involved. Form a team, join a team, walk individually, or donate. Click below to learn more and register.
"Compromised: Life Without Immunity" takes you inside the rarely-seen world of primary immunodeficiency. Through six powerful stories, discover how strength, support, and medical care make life possible despite seemingly impossible challenges. Join us for an upcoming screening or host your own.
When two of the internet's most engaging content creators—CDawgVA (Connor Colquhoun) and VTuber Ironmouse—came together to support the Immune Deficiency Foundation, something extraordinary happened. What began as a friendship between a charismatic streamer and a talented VTuber living with common variable immune deficiency (CVID) has grown into one of the most impactful partnerships in content creator fundraising.
If you are living with PI, think you might have PI, are a caregiver, a healthcare professional, or are just looking to learn more we can help.
website sessions linking the community to vital resources.
individuals turned to AskIDF to 1,910 PI-related questions.
individuals living with PI were supported and empowered.
*statistics based on 2024 Community Impact Report
The more we learn about plasma, the more we realize its life-saving potential. We need heroes to step up, donate, and save lives.
There are more than 450 primary immunodeficiencies, also known as inborn errors of immunity (IEI).
¡Bienvenidos! Para ver nuestros recursos disponibles, haga clic en el siguiente enlace.
Listen to the latest episode of the IDF Podcast, or one of our sub-series Undiagnosed or Bold Conversations.
Join IDF on YouTube to help spread awareness and education about PI and tune in to see what is happening.
Joining forces to protect the most vulnerable against infectious disease.
Learn more about all the ways to learn, connect, and engage with IDF, whether online and in person.
Browse the latest news articles, videos, and podcasts to find the most up-to-date information about advancements in PI treatments, portrayal in the media, and other IDF efforts.
Receive news and helpful resources to your cell phone or inbox. You can change or cancel your subscription at any time.
The Immune Deficiency Foundation improves the diagnosis, treatment, and quality of life for every person affected by primary immunodeficiency.
We foster a community that is connected, engaged, and empowered through advocacy, education, and research.
Combined Charity Campaign | CFC# 66309