Land use impacts on parasitic infection: a cross-sectional epidemiological study on the role of irrigated agriculture in schistosome infection in a dammed landscape

doi:10.1186/s40249-021-00816-5

. 2021 Mar 22;10(1):35.

doi: 10.1186/s40249-021-00816-5.

Land use impacts on parasitic infection: a cross-sectional epidemiological study on the role of irrigated agriculture in schistosome infection in a dammed landscape

Andrea J Lund ¹, David H Rehkopf ², Susanne H Sokolow ^{3

4}, M Moustapha Sam ⁵, Nicolas Jouanard ^{6

7}, Anne-Marie Schacht ^{5

7}, Simon Senghor ⁵, Assane Fall ⁵, Gilles Riveau ^{5

7}, Giulio A De Leo ⁴, David Lopez-Carr ⁸

Affiliations

¹ Emmett Interdisciplinary Program in Environment and Resources, Stanford University, 473 Via Ortega Suite 226, Stanford, CA, USA. andrea.janelle.lund@gmail.com.
² Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford University, 1701 Page Mill Road Room 229, Palo Alto, CA, USA.
³ Woods Institute for the Environment, Stanford University, 473 Via Ortega, Stanford, CA, USA.
⁴ Hopkins Marine Station, Stanford University, 120 Ocean View Blvd, Pacific Grove, CA, USA.
⁵ Centre de Recherche Biomédicale-Espoir Pour La Sante, 263 Route de la Corniche, BP 226, Saint-Louis, Sénégal.
⁶ Station d'Innovation Aquacole, UGB Cote Cite SAED, BP 524, Saint-Louis, Sénégal.
⁷ Center for Infection and Immunology of Lille, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59800, Lille, France.
⁸ Department of Geography, University of California, 4836 Ellison Hall, Santa Barbara, CA, USA.

PMID: 33745442
PMCID: PMC7983278
DOI: 10.1186/s40249-021-00816-5

Land use impacts on parasitic infection: a cross-sectional epidemiological study on the role of irrigated agriculture in schistosome infection in a dammed landscape

Andrea J Lund et al. Infect Dis Poverty. 2021.

. 2021 Mar 22;10(1):35.

doi: 10.1186/s40249-021-00816-5.

Authors

Andrea J Lund ¹, David H Rehkopf ², Susanne H Sokolow ^{3

4}, M Moustapha Sam ⁵, Nicolas Jouanard ^{6

7}, Anne-Marie Schacht ^{5

7}, Simon Senghor ⁵, Assane Fall ⁵, Gilles Riveau ^{5

7}, Giulio A De Leo ⁴, David Lopez-Carr ⁸

Affiliations

¹ Emmett Interdisciplinary Program in Environment and Resources, Stanford University, 473 Via Ortega Suite 226, Stanford, CA, USA. andrea.janelle.lund@gmail.com.
² Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford University, 1701 Page Mill Road Room 229, Palo Alto, CA, USA.
³ Woods Institute for the Environment, Stanford University, 473 Via Ortega, Stanford, CA, USA.
⁴ Hopkins Marine Station, Stanford University, 120 Ocean View Blvd, Pacific Grove, CA, USA.
⁵ Centre de Recherche Biomédicale-Espoir Pour La Sante, 263 Route de la Corniche, BP 226, Saint-Louis, Sénégal.
⁶ Station d'Innovation Aquacole, UGB Cote Cite SAED, BP 524, Saint-Louis, Sénégal.
⁷ Center for Infection and Immunology of Lille, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59800, Lille, France.
⁸ Department of Geography, University of California, 4836 Ellison Hall, Santa Barbara, CA, USA.

PMID: 33745442
PMCID: PMC7983278
DOI: 10.1186/s40249-021-00816-5

Abstract

Background: Water resources development promotes agricultural expansion and food security. But are these benefits offset by increased infectious disease risk? Dam construction on the Senegal River in 1986 was followed by agricultural expansion and increased transmission of human schistosomes. Yet the mechanisms linking these two processes at the individual and household levels remain unclear. We investigated the association between household land use and schistosome infection in children.

Methods: We analyzed cross-sectional household survey data (n = 655) collected in 16 rural villages in August 2016 across demographic, socio-economic and land use dimensions, which were matched to Schistosoma haematobium (n = 1232) and S. mansoni (n = 1222) infection data collected from school-aged children. Mixed effects regression determined the relationship between irrigated area and schistosome infection presence and intensity.

Results: Controlling for socio-economic and demographic risk factors, irrigated area cultivated by a household was associated with an increase in the presence of S. haematobium infection (odds ratio [OR] = 1.14; 95% confidence interval [95% CI]: 1.03-1.28) but not S. mansoni infection (OR = 1.02; 95% CI: 0.93-1.11). Associations between infection intensity and irrigated area were positive but imprecise (S. haematobium: rate ratio [RR] = 1.05; 95% CI: 0.98-1.13, S. mansoni: RR = 1.09; 95% CI: 0.89-1.32).

Conclusions: Household engagement in irrigated agriculture increases individual risk of S. haematobium but not S. mansoni infection. Increased contact with irrigated landscapes likely drives exposure, with greater impacts on households relying on agricultural livelihoods.

Keywords: Agriculture; Exposure; Livelihoods; Planetary health; Schistosomiasis; Senegal; Water contact.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1

Fig. 1

Study villages along the lower Senegal River along with freshwater bodies and the Diama Dam

Fig. 2

Fig. 2

Assessment of sample size and missing data from combining household survey and parasitological data

Fig. 3

Fig. 3

Estimates and 95% CIs for relationship between irrigated area and infection a presence and b intensity

See this image and copyright information in PMC

References

1. Molden D, editor. Water for food, water for life: a comprehensive assessment of water management in agriculture. London; Sterling, VA: Earthscan; 2007. 645 p.
1. Rohr JR, Barrett CB, Civitello DJ, Craft ME, Delius B, De Leo GA, et al. Emerging human infectious diseases and the links to global food production. Nat Sustain. 2019;2(6):445–456. doi: 10.1038/s41893-019-0293-3. - DOI - PMC - PubMed
1. Shah HA, Huxley P, Elmes J, Murray KA. Agricultural land-uses consistently exacerbate infectious disease risks in Southeast Asia. Nat Commun. 2019;10(1):1–13. doi: 10.1038/s41467-018-07882-8. - DOI - PMC - PubMed
1. Ngonghala CN, De Leo GA, Pascual MM, Keenan DC, Dobson AP, Bonds MH. General ecological models for human subsistence, health and poverty. Nat Ecol Evol. 2017;1(8):1153–1159. doi: 10.1038/s41559-017-0221-8. - DOI - PubMed
1. Bonds MH, Keenan DC, Rohani P, Sachs JD. Poverty trap formed by the ecology of infectious diseases. Proc R Soc Lond B Biol Sci. 2010;277(1685):1185–1192. - PMC - PubMed

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[1] Molden D, editor. Water for food, water for life: a comprehensive assessment of water management in agriculture. London; Sterling, VA: Earthscan; 2007. 645 p.

[2] Molden D, editor. Water for food, water for life: a comprehensive assessment of water management in agriculture. London; Sterling, VA: Earthscan; 2007. 645 p.

[3] Rohr JR, Barrett CB, Civitello DJ, Craft ME, Delius B, De Leo GA, et al. Emerging human infectious diseases and the links to global food production. Nat Sustain. 2019;2(6):445–456. doi: 10.1038/s41893-019-0293-3. - DOI - PMC - PubMed

[4] Rohr JR, Barrett CB, Civitello DJ, Craft ME, Delius B, De Leo GA, et al. Emerging human infectious diseases and the links to global food production. Nat Sustain. 2019;2(6):445–456. doi: 10.1038/s41893-019-0293-3. - DOI - PMC - PubMed

[5] Shah HA, Huxley P, Elmes J, Murray KA. Agricultural land-uses consistently exacerbate infectious disease risks in Southeast Asia. Nat Commun. 2019;10(1):1–13. doi: 10.1038/s41467-018-07882-8. - DOI - PMC - PubMed

[6] Shah HA, Huxley P, Elmes J, Murray KA. Agricultural land-uses consistently exacerbate infectious disease risks in Southeast Asia. Nat Commun. 2019;10(1):1–13. doi: 10.1038/s41467-018-07882-8. - DOI - PMC - PubMed

[7] Ngonghala CN, De Leo GA, Pascual MM, Keenan DC, Dobson AP, Bonds MH. General ecological models for human subsistence, health and poverty. Nat Ecol Evol. 2017;1(8):1153–1159. doi: 10.1038/s41559-017-0221-8. - DOI - PubMed

[8] Ngonghala CN, De Leo GA, Pascual MM, Keenan DC, Dobson AP, Bonds MH. General ecological models for human subsistence, health and poverty. Nat Ecol Evol. 2017;1(8):1153–1159. doi: 10.1038/s41559-017-0221-8. - DOI - PubMed

[9] Bonds MH, Keenan DC, Rohani P, Sachs JD. Poverty trap formed by the ecology of infectious diseases. Proc R Soc Lond B Biol Sci. 2010;277(1685):1185–1192. - PMC - PubMed

[10] Bonds MH, Keenan DC, Rohani P, Sachs JD. Poverty trap formed by the ecology of infectious diseases. Proc R Soc Lond B Biol Sci. 2010;277(1685):1185–1192. - PMC - PubMed

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Land use impacts on parasitic infection: a cross-sectional epidemiological study on the role of irrigated agriculture in schistosome infection in a dammed landscape

Affiliations

Land use impacts on parasitic infection: a cross-sectional epidemiological study on the role of irrigated agriculture in schistosome infection in a dammed landscape

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources