Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with "screen, diagnose and treat" using innovative tools and strategies

doi:10.1371/journal.pntd.0008738

. 2020 Nov 12;14(11):e0008738.

doi: 10.1371/journal.pntd.0008738. eCollection 2020 Nov.

Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with "screen, diagnose and treat" using innovative tools and strategies

Joseph Mathu Ndung'u ¹, Alain Boulangé ^{2

3}, Albert Picado ¹, Albert Mugenyi ⁴, Allan Mortensen ⁵, Andrew Hope ⁶, Brahim Guihini Mollo ⁷, Bruno Bucheton ^{8

9}, Charles Wamboga ¹⁰, Charles Waiswa ⁴, Dramane Kaba ¹¹, Enock Matovu ¹², Fabrice Courtin ^{8

11}, Gala Garrod ⁶, Geoffrey Gimonneau ^{2

3}, Georgina V Bingham ⁵, Hassane Mahamat Hassane ⁷, Inaki Tirados ⁶, Isabel Saldanha ⁶, Jacques Kabore ², Jean-Baptiste Rayaisse ², Jean-Mathieu Bart ⁸, Jessica Lingley ⁶, Johan Esterhuizen ⁶, Joshua Longbottom ⁶, Justin Pulford ⁶, Lingue Kouakou ¹³, Lassina Sanogo ², Lucas Cunningham ⁶, Mamadou Camara ⁸, Mathurin Koffi ¹⁴, Michelle Stanton ⁶, Mike Lehane ⁶, Moise Saa Kagbadouno ⁹, Oumou Camara ⁹, Paul Bessell ¹⁵, Peka Mallaye ¹⁶, Philippe Solano ⁸, Richard Selby ⁶, Sophie Dunkley ⁶, Steve Torr ⁶, Sylvain Biéler ¹, Veerle Lejon ⁸, Vincent Jamonneau ^{8

10}, Wilfried Yoni ², Zachary Katz ¹

Affiliations

¹ Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland.
² Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Bobo Dioulasso, Burkina Faso.
³ Centre International de Recherche Agronomique pour le Développement (CIRAD), UMR INTERTRYP, Montpellier, France.
⁴ Coordinating Office for Control of Trypanosomiasis in Uganda (COCTU), Entebbe, Uganda.
⁵ Vestergaard SA, Lausanne, Switzerland.
⁶ Liverpool School of Tropical Medicine (LSTM), Liverpool, United Kingdom.
⁷ Institut de Recherche en Elevage pour le Développement (IRED), N'Djamena, Chad.
⁸ Institut de Recherche pour le Développement (IRD), INTERTRYP, CIRAD, Université Montpellier, Montpellier, France.
⁹ Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Conakry, Guinea.
¹⁰ Ministry of Health (MOH), Kampala, Uganda.
¹¹ Institut Pierre Richet/Institut National de Santé Publique (IPR/INSP), Bouaké, Côte d'Ivoire.
¹² College of Veterinary Medicine, Animal Resources and Biosecurity (COVAB), Makerere University, Kampala, Uganda.
¹³ Programme National d'Elimination de la THA (PNETHA), Abidjan, Côte d'Ivoire.
¹⁴ Université Jean Lorougnon Guédé (UJLoG), Daloa, Côte d'Ivoire.
¹⁵ Epi Interventions, Edinburgh, United Kingdom.
¹⁶ Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Chad.

PMID: 33180776
PMCID: PMC7660505
DOI: 10.1371/journal.pntd.0008738

Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with "screen, diagnose and treat" using innovative tools and strategies

Joseph Mathu Ndung'u et al. PLoS Negl Trop Dis. 2020.

. 2020 Nov 12;14(11):e0008738.

doi: 10.1371/journal.pntd.0008738. eCollection 2020 Nov.

Authors

Joseph Mathu Ndung'u ¹, Alain Boulangé ^{2

3}, Albert Picado ¹, Albert Mugenyi ⁴, Allan Mortensen ⁵, Andrew Hope ⁶, Brahim Guihini Mollo ⁷, Bruno Bucheton ^{8

9}, Charles Wamboga ¹⁰, Charles Waiswa ⁴, Dramane Kaba ¹¹, Enock Matovu ¹², Fabrice Courtin ^{8

11}, Gala Garrod ⁶, Geoffrey Gimonneau ^{2

3}, Georgina V Bingham ⁵, Hassane Mahamat Hassane ⁷, Inaki Tirados ⁶, Isabel Saldanha ⁶, Jacques Kabore ², Jean-Baptiste Rayaisse ², Jean-Mathieu Bart ⁸, Jessica Lingley ⁶, Johan Esterhuizen ⁶, Joshua Longbottom ⁶, Justin Pulford ⁶, Lingue Kouakou ¹³, Lassina Sanogo ², Lucas Cunningham ⁶, Mamadou Camara ⁸, Mathurin Koffi ¹⁴, Michelle Stanton ⁶, Mike Lehane ⁶, Moise Saa Kagbadouno ⁹, Oumou Camara ⁹, Paul Bessell ¹⁵, Peka Mallaye ¹⁶, Philippe Solano ⁸, Richard Selby ⁶, Sophie Dunkley ⁶, Steve Torr ⁶, Sylvain Biéler ¹, Veerle Lejon ⁸, Vincent Jamonneau ^{8

10}, Wilfried Yoni ², Zachary Katz ¹

Affiliations

¹ Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland.
² Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Bobo Dioulasso, Burkina Faso.
³ Centre International de Recherche Agronomique pour le Développement (CIRAD), UMR INTERTRYP, Montpellier, France.
⁴ Coordinating Office for Control of Trypanosomiasis in Uganda (COCTU), Entebbe, Uganda.
⁵ Vestergaard SA, Lausanne, Switzerland.
⁶ Liverpool School of Tropical Medicine (LSTM), Liverpool, United Kingdom.
⁷ Institut de Recherche en Elevage pour le Développement (IRED), N'Djamena, Chad.
⁸ Institut de Recherche pour le Développement (IRD), INTERTRYP, CIRAD, Université Montpellier, Montpellier, France.
⁹ Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Conakry, Guinea.
¹⁰ Ministry of Health (MOH), Kampala, Uganda.
¹¹ Institut Pierre Richet/Institut National de Santé Publique (IPR/INSP), Bouaké, Côte d'Ivoire.
¹² College of Veterinary Medicine, Animal Resources and Biosecurity (COVAB), Makerere University, Kampala, Uganda.
¹³ Programme National d'Elimination de la THA (PNETHA), Abidjan, Côte d'Ivoire.
¹⁴ Université Jean Lorougnon Guédé (UJLoG), Daloa, Côte d'Ivoire.
¹⁵ Epi Interventions, Edinburgh, United Kingdom.
¹⁶ Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Chad.

PMID: 33180776
PMCID: PMC7660505
DOI: 10.1371/journal.pntd.0008738

No abstract available

PubMed Disclaimer

Conflict of interest statement

Allan Mortensen and Georgina Bingham are employees of Vestergaard SA, which manufactures the Tiny Targets used in this project. They however play no role in implementation of the project.

Figures

Fig 1

Fig 1

Tiny Targets used to control (A) G. fuscipes ssp. in Central Africa and (B) G. palpalis ssp. in West Africa. Image credit: (A) Sophie Dunkley, LSTM; (B) Fabrice Courtin, IRD.

Fig 2

Fig 2. Regions where Tiny Targets (red areas) are deployed in countries in the Trypa-NO!.

Partnership Fig 2A areas of Tiny Target deployments in Chad; Fig 2B Côte d’Ivoire; Fig 2C Guinea; and Fig 2D Uganda.

See this image and copyright information in PMC

References

1. World Health Organization; Accelerating work to overcome neglected tropical diseases: a roadmap for implementation. Geneva, 2012; Available from: http://whqlibdoc.who.int/hq/2012/WHO_HTM_NTD_2012.1_eng.pdf.
1. Franco JR, Cecchi G, Priotto G, Paone M, Diarra A, Grout L, et al. Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018. PLoS Negl Trop Dis. 2020;14(5):e0008261 10.1371/journal.pntd.0008261 - DOI - PMC - PubMed
1. Buscher P, Cecchi G, Jamonneau V, Priotto G. Human African trypanosomiasis. Lancet. 2017;390(10110):2397–2409. 10.1016/S0140-6736(17)31510-6 - DOI - PubMed
1. Wamboga C, Matovu E, Bessell PR, Picado A, Bieler S, Ndung'u JM. Enhanced passive screening and diagnosis for gambiense human African trypanosomiasis in north-western Uganda—Moving towards elimination. PLoS One. 2017;12(10):e0186429 10.1371/journal.pone.0186429 - DOI - PMC - PubMed
1. Courtin F, Camara M, Rayaisse JB, Kagbadouno M, Dama E, Camara O, et al. Reducing Human-Tsetse Contact Significantly Enhances the Efficacy of Sleeping Sickness Active Screening Campaigns: A Promising Result in the Context of Elimination. PLoS Negl Trop Dis. 2015;9(8):e0003727 10.1371/journal.pntd.0003727 - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources

[1] World Health Organization; Accelerating work to overcome neglected tropical diseases: a roadmap for implementation. Geneva, 2012; Available from: http://whqlibdoc.who.int/hq/2012/WHO_HTM_NTD_2012.1_eng.pdf.

[2] World Health Organization; Accelerating work to overcome neglected tropical diseases: a roadmap for implementation. Geneva, 2012; Available from: http://whqlibdoc.who.int/hq/2012/WHO_HTM_NTD_2012.1_eng.pdf.

[3] Franco JR, Cecchi G, Priotto G, Paone M, Diarra A, Grout L, et al. Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018. PLoS Negl Trop Dis. 2020;14(5):e0008261 10.1371/journal.pntd.0008261 - DOI - PMC - PubMed

[4] Franco JR, Cecchi G, Priotto G, Paone M, Diarra A, Grout L, et al. Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018. PLoS Negl Trop Dis. 2020;14(5):e0008261 10.1371/journal.pntd.0008261 - DOI - PMC - PubMed

[5] Buscher P, Cecchi G, Jamonneau V, Priotto G. Human African trypanosomiasis. Lancet. 2017;390(10110):2397–2409. 10.1016/S0140-6736(17)31510-6 - DOI - PubMed

[6] Buscher P, Cecchi G, Jamonneau V, Priotto G. Human African trypanosomiasis. Lancet. 2017;390(10110):2397–2409. 10.1016/S0140-6736(17)31510-6 - DOI - PubMed

[7] Wamboga C, Matovu E, Bessell PR, Picado A, Bieler S, Ndung'u JM. Enhanced passive screening and diagnosis for gambiense human African trypanosomiasis in north-western Uganda—Moving towards elimination. PLoS One. 2017;12(10):e0186429 10.1371/journal.pone.0186429 - DOI - PMC - PubMed

[8] Wamboga C, Matovu E, Bessell PR, Picado A, Bieler S, Ndung'u JM. Enhanced passive screening and diagnosis for gambiense human African trypanosomiasis in north-western Uganda—Moving towards elimination. PLoS One. 2017;12(10):e0186429 10.1371/journal.pone.0186429 - DOI - PMC - PubMed

[9] Courtin F, Camara M, Rayaisse JB, Kagbadouno M, Dama E, Camara O, et al. Reducing Human-Tsetse Contact Significantly Enhances the Efficacy of Sleeping Sickness Active Screening Campaigns: A Promising Result in the Context of Elimination. PLoS Negl Trop Dis. 2015;9(8):e0003727 10.1371/journal.pntd.0003727 - DOI - PMC - PubMed

[10] Courtin F, Camara M, Rayaisse JB, Kagbadouno M, Dama E, Camara O, et al. Reducing Human-Tsetse Contact Significantly Enhances the Efficacy of Sleeping Sickness Active Screening Campaigns: A Promising Result in the Context of Elimination. PLoS Negl Trop Dis. 2015;9(8):e0003727 10.1371/journal.pntd.0003727 - DOI - PMC - PubMed

Account

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with "screen, diagnose and treat" using innovative tools and strategies

Affiliations

Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with "screen, diagnose and treat" using innovative tools and strategies

Authors

Affiliations

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources