Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects

doi:10.1371/journal.pntd.0008307

Review

. 2020 Aug 27;14(8):e0008307.

doi: 10.1371/journal.pntd.0008307. eCollection 2020 Aug.

Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects

Lamis Y M Elkheir ^{1

2}, Rayan Haroun ², Magdi Awadalla Mohamed ^{2

3}, Ahmed Hassan Fahal ¹

Affiliations

PMID: 32853199
PMCID: PMC7452721
DOI: 10.1371/journal.pntd.0008307

Review

Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects

Lamis Y M Elkheir et al. PLoS Negl Trop Dis. 2020.

. 2020 Aug 27;14(8):e0008307.

doi: 10.1371/journal.pntd.0008307. eCollection 2020 Aug.

Authors

Lamis Y M Elkheir ^{1

2}, Rayan Haroun ², Magdi Awadalla Mohamed ^{2

3}, Ahmed Hassan Fahal ¹

Affiliations

¹ The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.
² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
³ Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Jouf, KSA.

PMID: 32853199
PMCID: PMC7452721
DOI: 10.1371/journal.pntd.0008307

No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1

Fig 1. A massive eumycetoma lesion with multiple discharging sinuses and black grains.

Fig 2

Fig 2. Massive postoperative recurrence after adequate itraconazole treatment for one year.

Fig 3

Fig 3. Melanin in histopathology.

Fig 4

Fig 4. Massive thick capsule around the eumycetoma lesions.

Fig 5

Fig 5. Photomicroscopy showing M. mycetomatis grains well encapsulated with excessive collagen following treatment with itraconazole (hematoxylin–eosin X 400).

Fig 6

Fig 6. The use of traditional medicine for mycetoma.

See this image and copyright information in PMC

References

1. WHO | Mycetoma. WHO. World Health Organization; 2016; Available: https://www.who.int/buruli/mycetoma/en/
1. Relhan V, Mahajan K, Agarwal P, Garg VK. Mycetoma: An Update. Indian J Dermatol. Wolters Kluwer—Medknow Publications; 2017;62: 332–340. 10.4103/ijd.IJD_476_16 - DOI - PMC - PubMed
1. Nenoff P, van de Sande WWJ, Fahal AH, Reinel D, Schöfer H. Eumycetoma and actinomycetoma—an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. J Eur Acad Dermatology Venereol. 2015;29: 1873–1883. 10.1111/jdv.13008 - DOI - PubMed
1. Ahmed AO, van Leeuwen W, Fahal A, van de Sande W, Verbrugh H, van Belkum A. Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis. 2004;4: 566–574. 10.1016/S1473-3099(04)01131-4 - DOI - PubMed
1. Fahal AH. Mycetoma: a thorn in the flesh. Trans R Soc Trop Med Hyg. 2004;98: 3–11. 10.1016/s0035-9203(03)00009-9 - DOI - PubMed

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[1] WHO | Mycetoma. WHO. World Health Organization; 2016; Available: https://www.who.int/buruli/mycetoma/en/

[2] WHO | Mycetoma. WHO. World Health Organization; 2016; Available: https://www.who.int/buruli/mycetoma/en/

[3] Relhan V, Mahajan K, Agarwal P, Garg VK. Mycetoma: An Update. Indian J Dermatol. Wolters Kluwer—Medknow Publications; 2017;62: 332–340. 10.4103/ijd.IJD_476_16 - DOI - PMC - PubMed

[4] Relhan V, Mahajan K, Agarwal P, Garg VK. Mycetoma: An Update. Indian J Dermatol. Wolters Kluwer—Medknow Publications; 2017;62: 332–340. 10.4103/ijd.IJD_476_16 - DOI - PMC - PubMed

[5] Nenoff P, van de Sande WWJ, Fahal AH, Reinel D, Schöfer H. Eumycetoma and actinomycetoma—an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. J Eur Acad Dermatology Venereol. 2015;29: 1873–1883. 10.1111/jdv.13008 - DOI - PubMed

[6] Nenoff P, van de Sande WWJ, Fahal AH, Reinel D, Schöfer H. Eumycetoma and actinomycetoma—an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. J Eur Acad Dermatology Venereol. 2015;29: 1873–1883. 10.1111/jdv.13008 - DOI - PubMed

[7] Ahmed AO, van Leeuwen W, Fahal A, van de Sande W, Verbrugh H, van Belkum A. Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis. 2004;4: 566–574. 10.1016/S1473-3099(04)01131-4 - DOI - PubMed

[8] Ahmed AO, van Leeuwen W, Fahal A, van de Sande W, Verbrugh H, van Belkum A. Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis. 2004;4: 566–574. 10.1016/S1473-3099(04)01131-4 - DOI - PubMed

[9] Fahal AH. Mycetoma: a thorn in the flesh. Trans R Soc Trop Med Hyg. 2004;98: 3–11. 10.1016/s0035-9203(03)00009-9 - DOI - PubMed

[10] Fahal AH. Mycetoma: a thorn in the flesh. Trans R Soc Trop Med Hyg. 2004;98: 3–11. 10.1016/s0035-9203(03)00009-9 - DOI - PubMed

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Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects

Affiliations

Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects

Authors

Affiliations

Conflict of interest statement

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References

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