Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

doi:10.1038/s41577-019-0177-9

Review

. 2019 Sep;19(9):563-572.

doi: 10.1038/s41577-019-0177-9.

Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

Niharika A Duggal ¹, Grace Niemiro ², Stephen D R Harridge ³, Richard J Simpson ^{2

4

5}, Janet M Lord ^{6

7}

Affiliations

¹ MRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
² Department of Pediatrics, University of Arizona, Tucson, AZ, USA.
³ Centre for Human and Applied Physiological Sciences, King's College London, London, UK.
⁴ Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA.
⁵ Department of Immunobiology, University of Arizona, Tucson, AZ, USA.
⁶ MRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. j.m.lord@bham.ac.uk.
⁷ NIHR Birmingham Biomedical Research Centre, University Hospital Birmingham, Birmingham, UK. j.m.lord@bham.ac.uk.

PMID: 31175337
DOI: 10.1038/s41577-019-0177-9

Review

Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

Niharika A Duggal et al. Nat Rev Immunol. 2019 Sep.

. 2019 Sep;19(9):563-572.

doi: 10.1038/s41577-019-0177-9.

Authors

Niharika A Duggal ¹, Grace Niemiro ², Stephen D R Harridge ³, Richard J Simpson ^{2

4

5}, Janet M Lord ^{6

7}

Affiliations

¹ MRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
² Department of Pediatrics, University of Arizona, Tucson, AZ, USA.
³ Centre for Human and Applied Physiological Sciences, King's College London, London, UK.
⁴ Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA.
⁵ Department of Immunobiology, University of Arizona, Tucson, AZ, USA.
⁶ MRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. j.m.lord@bham.ac.uk.
⁷ NIHR Birmingham Biomedical Research Centre, University Hospital Birmingham, Birmingham, UK. j.m.lord@bham.ac.uk.

PMID: 31175337
DOI: 10.1038/s41577-019-0177-9

Abstract

Remodelling of the immune system with age - immunosenescence - is a substantial contributor to poor health in older adults, with increasing risk of infections, cancer and chronic inflammatory disease contributing to age-related multi-morbidity. What is seldom considered when examining the immune response of an aged individual is that the immune system is profoundly influenced by physical activity. Habitual physical activity levels decline with age, with significant consequences for muscle mass and function. Skeletal muscle is a major immune regulatory organ and generates a range of proteins, termed myokines, which have anti-inflammatory and immunoprotective effects. Several studies indicate that maintaining physical activity has immune benefits in older adults, for example, it reduces the systemic inflammation associated with chronic age-related diseases. Here, we discuss how physical activity can prevent or ameliorate age-related multi-morbidity by boosting immune function, and we consider whether physical activity could improve immunotherapy outcomes in age-related conditions such as cancer.

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References

1. Kirkwood, T. B. L. Why and how are we living longer? Exp. Physiol. 102, 1067–1074 (2017). - PubMed
1. Salomon, J. A. et al. Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010. Lancet 380, 2144–2162 (2012). - PubMed
1. Rocca, W. A. et al. Prevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity. Mayo Clin. Proc. 89, 1336–1349 (2014). - PubMed - PMC
1. Colchero, F. et al. The emergence of longevous populations. Proc. Natl Acad. Sci. USA 113, E7681–E7690 (2016). - PubMed
1. Booth, F. W., Chakravarthy, M. V. & Spangenburg, E. E. Exercise and gene expression: physiological regulation of the human genome through physical activity. J. Physiol. 543, 399–411 (2002). - PubMed - PMC

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[1] Kirkwood, T. B. L. Why and how are we living longer? Exp. Physiol. 102, 1067–1074 (2017). - PubMed

[2] Kirkwood, T. B. L. Why and how are we living longer? Exp. Physiol. 102, 1067–1074 (2017). - PubMed

[3] Salomon, J. A. et al. Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010. Lancet 380, 2144–2162 (2012). - PubMed

[4] Salomon, J. A. et al. Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010. Lancet 380, 2144–2162 (2012). - PubMed

[5] Rocca, W. A. et al. Prevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity. Mayo Clin. Proc. 89, 1336–1349 (2014). - PubMed - PMC

[6] Rocca, W. A. et al. Prevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity. Mayo Clin. Proc. 89, 1336–1349 (2014). - PubMed - PMC

[7] Colchero, F. et al. The emergence of longevous populations. Proc. Natl Acad. Sci. USA 113, E7681–E7690 (2016). - PubMed

[8] Colchero, F. et al. The emergence of longevous populations. Proc. Natl Acad. Sci. USA 113, E7681–E7690 (2016). - PubMed

[9] Booth, F. W., Chakravarthy, M. V. & Spangenburg, E. E. Exercise and gene expression: physiological regulation of the human genome through physical activity. J. Physiol. 543, 399–411 (2002). - PubMed - PMC

[10] Booth, F. W., Chakravarthy, M. V. & Spangenburg, E. E. Exercise and gene expression: physiological regulation of the human genome through physical activity. J. Physiol. 543, 399–411 (2002). - PubMed - PMC

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Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

Affiliations

Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

Authors

Affiliations

Abstract

References

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MeSH terms

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Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical