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. 2019 Oct 15;69(9):1628-1630.
doi: 10.1093/cid/ciz172.

Loa loa Microfilariae in Skin Snips: Consequences for Onchocerciasis Monitoring and Evaluation in L. loa-Endemic Areas

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Loa loa Microfilariae in Skin Snips: Consequences for Onchocerciasis Monitoring and Evaluation in L. loa-Endemic Areas

Hugues C Nana-Djeunga et al. Clin Infect Dis. .

Abstract

The specificity of skin snips for onchocerciasis diagnoses is considered to be almost 100%. Our molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa-infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas.

Keywords: Loa loa; Onchocerca volvulus; diagnosis; filariasis; skin snip.

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Figures

Figure 1.
Figure 1.
Relationship between Loa loa microfilarial density and the (A) percentage of positive skin snips and (B) numbers of microfilariae found in skin snips. Q1, Q2, Q3 and Q4 represent the quartiles of L. loa microfilarial densities.

References

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