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. 2019 Jan;165(1):1-3.
doi: 10.1099/mic.0.000707. Epub 2018 Nov 13.

Coxiella burnetii: A Pathogenic Intracellular Acidophile

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Coxiella burnetii: A Pathogenic Intracellular Acidophile

Edward I Shaw et al. Microbiology (Reading). 2019 Jan.

Abstract

Coxiella burnetii is an obligate intracellular pathogen that causes acute and chronic Q fever. C. burnetii grows within a eukaryotic host cell in a vacuole highly similar to a phagolysosome. Found worldwide, this environmentally stable pathogen is maintained in nature via chronic infection of ruminants. Aerosol-mediated infection of humans results in infection and usurpation of alveolar macrophages through mechanisms using a bacterial Type 4B Secretion System and secreted effector proteins. Advances in axenic culture and genetic systems are changing our understanding of the pathogen's physiology and intimate molecular manipulations of host cells during infection.

Keywords: ACCM; Coxiella; Intracellular pathogenesis; Q-fever; Type 4B Secretion System.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

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