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. 2017 Jul 1;65(1):150-153.
doi: 10.1093/cid/cix245.

Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent

Affiliations

Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent

Ricardo Molina et al. Clin Infect Dis. .

Abstract

We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.

Keywords: control; leishmaniasis; post–kala-azar dermal leishmaniasis; xenodiagnosis.

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Figures

Figure 1.
Figure 1.
Post–kala-azar dermal leishmaniasis patients included in the xenodiagnosis experiments. A, Patient 1: macular (green arrows) and nodular (white arrows) lesions. B, Direct xenodiagnosis using a small tube. C and D, Patient 2: nodular lesions on forearm and abdomen. E, Direct xenodiagnosis placing hand in cage with sand flies. F and G, Patient 3: extensive macular lesions on forearms, abdomen, and back.

References

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