HIV-Associated Cryptococcal Meningitis: Bridging the Gap Between Developed and Resource-Limited Settings

doi:10.1007/s40588-016-0035-5

Review

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doi: 10.1007/s40588-016-0035-5. Epub 2016 Mar 17.

HIV-Associated Cryptococcal Meningitis: Bridging the Gap Between Developed and Resource-Limited Settings

Mark W Tenforde ¹, Rae Wake ², Tshepo Leeme ³, Joseph N Jarvis ⁴

Affiliations

¹ Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA USA ; University of Washington Medical Center, 1959 NE Pacific Street, Health Sciences Division #356423, Seattle, WA 98195 USA.
² Institute of Infection and Immunity, St. George's University of London, London, UK ; Centre for Opportunistic, Tropical and Hospital Infections, National Institute for Communicable Diseases, Johannesburg, South Africa ; National Institute for Communicable Diseases, 1 Modderfontein Road, Sandringham, Johannesburg, 2131 South Africa.
³ Botswana-UPenn Partnership, Gaborone, Botswana.
⁴ Botswana-UPenn Partnership, Gaborone, Botswana ; Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA ; Department of Clinical Research, Faculty of Infectious Diseases and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, UK.

PMID: 27257597
PMCID: PMC4845086
DOI: 10.1007/s40588-016-0035-5

Review

HIV-Associated Cryptococcal Meningitis: Bridging the Gap Between Developed and Resource-Limited Settings

Mark W Tenforde et al. Curr Clin Microbiol Rep. 2016.

. .&checktime(2016,3,92,':')-102.

doi: 10.1007/s40588-016-0035-5. Epub 2016 Mar 17.

Authors

Mark W Tenforde ¹, Rae Wake ², Tshepo Leeme ³, Joseph N Jarvis ⁴

Affiliations

¹ Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA USA ; University of Washington Medical Center, 1959 NE Pacific Street, Health Sciences Division #356423, Seattle, WA 98195 USA.
² Institute of Infection and Immunity, St. George's University of London, London, UK ; Centre for Opportunistic, Tropical and Hospital Infections, National Institute for Communicable Diseases, Johannesburg, South Africa ; National Institute for Communicable Diseases, 1 Modderfontein Road, Sandringham, Johannesburg, 2131 South Africa.
³ Botswana-UPenn Partnership, Gaborone, Botswana.
⁴ Botswana-UPenn Partnership, Gaborone, Botswana ; Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA ; Department of Clinical Research, Faculty of Infectious Diseases and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, UK.

PMID: 27257597
PMCID: PMC4845086
DOI: 10.1007/s40588-016-0035-5

Abstract

Cryptococcal meningitis is a major cause of HIV-associated morbidity and mortality worldwide. Most cases occur in low-income countries, where over half of patients die within 10 weeks of diagnosis compared to as few as 10 % of patients from developed countries. A host of factors, spanning the HIV care continuum, are responsible for this gap in treatment outcomes between developed and resource-limited settings. We explore factors responsible for this outcomes gap and describe low-cost, highly effective measures that can be implemented immediately to improve outcomes in resource-limited settings. We also explore health-system challenges that must be addressed to reduce mortality further, recent research in disease prevention, and novel short-course treatment regimens that, if efficacious, could be implemented in resource-limited settings where the cost of standard treatment regimens is currently prohibitive.

Keywords: Cryptococcal meningitis; Health system strengthening; Prevention; Resource-limited settings.

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References

1. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009;23(4):525–30. doi: 10.1097/QAD.0b013e328322ffac. - DOI - PubMed
1. Lawn SD, Harries AD, Anglaret X, Myer L, Wood R. Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS. 2008;22(15):1897–908. doi: 10.1097/QAD.0b013e32830007cd. - DOI - PMC - PubMed
1. Special issue: 9th International Conference on Cryptococcus and Cryptococcosis, 15–19 May 2014, Amsterdam, The Netherlands. Scientific programme. Mycoses, 57:1–4. doi:10.1111/myc.12202. - PubMed
1. Powderly WG. Cryptococcal meningitis and AIDS. Clin Infect Dis. 1993;17(5):837–42. doi: 10.1093/clinids/17.5.837. - DOI - PubMed
1. Bicanic T, Harrison TS. Cryptococcal meningitis. Br Med Bull. 2004;72:99–118. doi: 10.1093/bmb/ldh043. - DOI - PubMed

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[1] Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009;23(4):525–30. doi: 10.1097/QAD.0b013e328322ffac. - DOI - PubMed

[2] Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009;23(4):525–30. doi: 10.1097/QAD.0b013e328322ffac. - DOI - PubMed

[3] Lawn SD, Harries AD, Anglaret X, Myer L, Wood R. Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS. 2008;22(15):1897–908. doi: 10.1097/QAD.0b013e32830007cd. - DOI - PMC - PubMed

[4] Lawn SD, Harries AD, Anglaret X, Myer L, Wood R. Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS. 2008;22(15):1897–908. doi: 10.1097/QAD.0b013e32830007cd. - DOI - PMC - PubMed

[5] Special issue: 9th International Conference on Cryptococcus and Cryptococcosis, 15–19 May 2014, Amsterdam, The Netherlands. Scientific programme. Mycoses, 57:1–4. doi:10.1111/myc.12202. - PubMed

[6] Special issue: 9th International Conference on Cryptococcus and Cryptococcosis, 15–19 May 2014, Amsterdam, The Netherlands. Scientific programme. Mycoses, 57:1–4. doi:10.1111/myc.12202. - PubMed

[7] Powderly WG. Cryptococcal meningitis and AIDS. Clin Infect Dis. 1993;17(5):837–42. doi: 10.1093/clinids/17.5.837. - DOI - PubMed

[8] Powderly WG. Cryptococcal meningitis and AIDS. Clin Infect Dis. 1993;17(5):837–42. doi: 10.1093/clinids/17.5.837. - DOI - PubMed

[9] Bicanic T, Harrison TS. Cryptococcal meningitis. Br Med Bull. 2004;72:99–118. doi: 10.1093/bmb/ldh043. - DOI - PubMed

[10] Bicanic T, Harrison TS. Cryptococcal meningitis. Br Med Bull. 2004;72:99–118. doi: 10.1093/bmb/ldh043. - DOI - PubMed

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HIV-Associated Cryptococcal Meningitis: Bridging the Gap Between Developed and Resource-Limited Settings

Affiliations

HIV-Associated Cryptococcal Meningitis: Bridging the Gap Between Developed and Resource-Limited Settings

Authors

Affiliations

Abstract

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous