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Review
. 2016 Mar;38(3):158-69.
doi: 10.1111/pim.12291.

Monitoring the outcomes of interventions against Taenia solium: options and suggestions

Affiliations
Review

Monitoring the outcomes of interventions against Taenia solium: options and suggestions

M W Lightowlers et al. Parasite Immunol. 2016 Mar.

Abstract

There is an increasing interest in reducing the incidence of human neurocysticercosis, caused by infection with the larval stage of Taenia solium. Several intervention trials are currently assessing various options for control of T. solium transmission. A critical aspect of these trials will be the evaluation of whether the interventions have been successful. However, there is no consensus about the most appropriate or valuable methods that should be used. Here, we undertake a critical assessment of the diagnostic tests which are currently available for human T. solium taeniasis and human and porcine cysticercosis, as well as their suitability for evaluation of intervention trial outcomes. Suggestions are made about which of the measures that are available for evaluation of T. solium interventions would be most suitable, and which methodologies are the most appropriate given currently available technologies. Suggestions are also made in relation to the most urgent research needs in order to address deficiencies in current diagnostic methods.

Keywords: Taenia solium; control; cysticercosis; diagnosis; neurocysticercosis; taeniasis.

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Figures

Figure 1
Figure 1
Number of observations required at the start and at the end of an intervention period in order to detect an 80% decrease in prevalence with a type I error of 5% and a power of 80% (Fisher's exact test, two sided). The numbers of observations are shown for each prevalence value plotted.

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