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. 2015 Oct;21(10):1704-10.
doi: 10.3201/eid2110.141928.

Characteristics and Factors Associated with Death among Patients Hospitalized for Severe Fever with Thrombocytopenia Syndrome, South Korea, 2013

Characteristics and Factors Associated with Death among Patients Hospitalized for Severe Fever with Thrombocytopenia Syndrome, South Korea, 2013

Jaeseung Shin et al. Emerg Infect Dis. 2015 Oct.

Abstract

In South Korea, nationwide surveillance for severe fever with thrombocytopenia syndrome (SFTS) began during 2013. Among 301 surveillance cases, 35 hospitalized case-patients in 25 areas were confirmed by using virologic testing, and 16 (46%) case-patients subsequently died. The SFTS cases occurred during May-November and peaked during June (9 cases, 26%). The incidence of SFTS was higher in the southern regions of South Korea. Age and neurologic symptoms, including decreased level of consciousness and slurred speech, were heavily associated with death; neurologic symptoms during the first week after disease onset were also associated with death. Although melena was common among patients who died, no other hemorrhagic manifestations were substantively more common among those who died. No effective treatments, including ribavirin, were identified. Expansion of SFTS surveillance to include the outpatient sector and development of an antibody test would enhance completeness of SFTS detection in South Korea.

Keywords: Bunyaviridae; Haemaphysalis longicornis; RNA virus; Severe fever with thrombocytopenia syndrome; South Korea; bunyavirus; cerebral hemorrhage; continuous renal replacement therapy; fungal pneumonia; intravenous immunoglobulin; phlebovirus; plasmapheresis; ribavirin; tickborne infections; vector-borne infections; viruses.

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Figures

Figure 1
Figure 1
Comparison of epidemic curve for severe fever with thrombocytopenia syndrome cases identified during 2013 and the number of Haemaphysalis longicornis ticks collected per month during 2011 and 2012, South Korea. A) Number of cases of severe fever with thrombocytopenia syndrome, by month of onset. B) Combined number of H. longicornis ticks collected, by month (6).
Figure 2
Figure 2
Geographic distribution of severe fever with thrombocytopenia syndrome cases, South Korea, 2013. Shading indicates incidence of cases per 1 million residents. Black circles indicate the approximate residential regions of the 16 case-patients who died.

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