Evidence of Hantavirus Infection Among Bats in Brazil

doi:10.4269/ajtmh.15-0032

. 2015 Aug;93(2):404-6.

doi: 10.4269/ajtmh.15-0032. Epub 2015 Jun 15.

Evidence of Hantavirus Infection Among Bats in Brazil

Gilberto Sabino-Santos Jr ¹, Felipe Gonçalves Motta Maia ², Thallyta Maria Vieira ², Renata de Lara Muylaert ², Sabrina Miranda Lima ², Cristieli Barros Gonçalves ², Patricia Doerl Barroso ², Maria Norma Melo ², Colleen B Jonsson ², Douglas Goodin ², Jorge Salazar-Bravo ², Luiz Tadeu Moraes Figueiredo ²

Affiliations

¹ Center for Virology Research, School of Medicine in Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil; Department of Ecology, São Paulo State University, Rio Claro, Brazil; Department of Microbiology and Immunology, University of Louisville Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Louisville, Kentucky; Department of Microbiology, National Institute for Mathematical and Biological Synthesis, Knoxville, Tennessee; Department of Geography, Kansas State University, Manhattan, Kansas; Department of Biological Sciences, Texas Tech University, Lubbock, Texas sabinogsj@usp.br.
² Center for Virology Research, School of Medicine in Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil; Department of Ecology, São Paulo State University, Rio Claro, Brazil; Department of Microbiology and Immunology, University of Louisville Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Louisville, Kentucky; Department of Microbiology, National Institute for Mathematical and Biological Synthesis, Knoxville, Tennessee; Department of Geography, Kansas State University, Manhattan, Kansas; Department of Biological Sciences, Texas Tech University, Lubbock, Texas.

PMID: 26078322
PMCID: PMC4530771
DOI: 10.4269/ajtmh.15-0032

Evidence of Hantavirus Infection Among Bats in Brazil

Gilberto Sabino-Santos Jr et al. Am J Trop Med Hyg. 2015 Aug.

. 2015 Aug;93(2):404-6.

doi: 10.4269/ajtmh.15-0032. Epub 2015 Jun 15.

Authors

Gilberto Sabino-Santos Jr ¹, Felipe Gonçalves Motta Maia ², Thallyta Maria Vieira ², Renata de Lara Muylaert ², Sabrina Miranda Lima ², Cristieli Barros Gonçalves ², Patricia Doerl Barroso ², Maria Norma Melo ², Colleen B Jonsson ², Douglas Goodin ², Jorge Salazar-Bravo ², Luiz Tadeu Moraes Figueiredo ²

Affiliations

¹ Center for Virology Research, School of Medicine in Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil; Department of Ecology, São Paulo State University, Rio Claro, Brazil; Department of Microbiology and Immunology, University of Louisville Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Louisville, Kentucky; Department of Microbiology, National Institute for Mathematical and Biological Synthesis, Knoxville, Tennessee; Department of Geography, Kansas State University, Manhattan, Kansas; Department of Biological Sciences, Texas Tech University, Lubbock, Texas sabinogsj@usp.br.
² Center for Virology Research, School of Medicine in Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil; Department of Ecology, São Paulo State University, Rio Claro, Brazil; Department of Microbiology and Immunology, University of Louisville Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Louisville, Kentucky; Department of Microbiology, National Institute for Mathematical and Biological Synthesis, Knoxville, Tennessee; Department of Geography, Kansas State University, Manhattan, Kansas; Department of Biological Sciences, Texas Tech University, Lubbock, Texas.

PMID: 26078322
PMCID: PMC4530771
DOI: 10.4269/ajtmh.15-0032

Abstract

Hantaviruses are zoonotic viruses harbored by rodents, bats, and shrews. At present, only rodent-borne hantaviruses are associated with severe illness in humans. New species of hantaviruses have been recently identified in bats and shrews greatly expanding the potential reservoirs and ranges of these viruses. Brazil has one of the highest incidences of hantavirus cardiopulmonary syndrome in South America, hence it is critical to know what is the prevalence of hantaviruses in Brazil. Although much is known about rodent reservoirs, little is known regarding bats. We captured 270 bats from February 2012 to April 2014. Serum was screened for the presence of antibodies against a recombinant nucleoprotein (rN) of Araraquara virus (ARAQV). The prevalence of antibody to hantavirus was 9/53 with an overall seroprevalence of 17%. Previous studies have shown only insectivorous bats to harbor hantavirus; however, in our study, of the nine seropositive bats, five were frugivorous, one was carnivorous, and three were sanguivorous phyllostomid bats.

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Figures

Figure 1.

Figure 1.

Study areas, highlighting the states of São Paulo and Minas Gerais in southeastern Brazil. The map shows cities where bats have been captured.

See this image and copyright information in PMC

References

1. Holmes EC, Zhang YZ. The evolution and emergence of hantaviruses. Curr Opi Virol. 2015;10:27–33. - PubMed
1. Brook CE, Dobson AP. Bats as ‘special’ reservoirs for emerging zoonotic pathogens. Trends Microbiol. 2015;23:172–180. - PMC - PubMed
1. Bennett SN, Gu SH, Kang HJ, Arai S, Yanagihara R. Reconstructing the evolutionary origins and phylogeography of hantaviruses. Trends Microbiol. 2014;22:473–482. - PMC - PubMed
1. Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L, Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song J-W, Yanagihara R. Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses. 2014;6:1897–1910. - PMC - PubMed
1. Guo W-P, Lin X-D, Wang W, Tian J-H, Cong M-L, Zhang H-L, Wang M-R, Zhou R-H, Wang J-B, Li M-H, Xu J, Holmes EC, Zhang Y-Z. Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents. PLoS Pathog. 2013;9:e1003159. - PMC - PubMed

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[1] Holmes EC, Zhang YZ. The evolution and emergence of hantaviruses. Curr Opi Virol. 2015;10:27–33. - PubMed

[2] Holmes EC, Zhang YZ. The evolution and emergence of hantaviruses. Curr Opi Virol. 2015;10:27–33. - PubMed

[3] Brook CE, Dobson AP. Bats as ‘special’ reservoirs for emerging zoonotic pathogens. Trends Microbiol. 2015;23:172–180. - PMC - PubMed

[4] Brook CE, Dobson AP. Bats as ‘special’ reservoirs for emerging zoonotic pathogens. Trends Microbiol. 2015;23:172–180. - PMC - PubMed

[5] Bennett SN, Gu SH, Kang HJ, Arai S, Yanagihara R. Reconstructing the evolutionary origins and phylogeography of hantaviruses. Trends Microbiol. 2014;22:473–482. - PMC - PubMed

[6] Bennett SN, Gu SH, Kang HJ, Arai S, Yanagihara R. Reconstructing the evolutionary origins and phylogeography of hantaviruses. Trends Microbiol. 2014;22:473–482. - PMC - PubMed

[7] Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L, Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song J-W, Yanagihara R. Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses. 2014;6:1897–1910. - PMC - PubMed

[8] Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L, Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song J-W, Yanagihara R. Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses. 2014;6:1897–1910. - PMC - PubMed

[9] Guo W-P, Lin X-D, Wang W, Tian J-H, Cong M-L, Zhang H-L, Wang M-R, Zhou R-H, Wang J-B, Li M-H, Xu J, Holmes EC, Zhang Y-Z. Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents. PLoS Pathog. 2013;9:e1003159. - PMC - PubMed

[10] Guo W-P, Lin X-D, Wang W, Tian J-H, Cong M-L, Zhang H-L, Wang M-R, Zhou R-H, Wang J-B, Li M-H, Xu J, Holmes EC, Zhang Y-Z. Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents. PLoS Pathog. 2013;9:e1003159. - PMC - PubMed

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Evidence of Hantavirus Infection Among Bats in Brazil

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Evidence of Hantavirus Infection Among Bats in Brazil

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