This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log in
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:918135.
doi: 10.1155/2014/918135. Epub 2014 Dec 4.

Mild clinical course of severe Fever with thrombocytopenia syndrome virus infection in an elderly Japanese patient

Affiliations

Mild clinical course of severe Fever with thrombocytopenia syndrome virus infection in an elderly Japanese patient

Yuko Ohagi et al. Case Rep Infect Dis. 2014.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious and hemorrhagic disease recently described in China and western Japan. A 71-year-old healthy Japanese woman noticed a tick biting her after harvesting in an orchard and removed it herself. She developed diarrhea, anorexia, and chills eight days later. Because these symptoms continued, she visited a primary care physician 6 days after the onset. Laboratory data revealed thrombocytopenia, leukocytopenia, and elevated liver enzymes. She was then referred to our hospital. Although not completely fulfilling the diagnostic criteria used in a retrospective study in Japan, SFTS was suspected, and we detected SFTS virus in the patient's blood using RT-PCR. However, she recovered without intensive treatment and severe complications 13 days after the onset. In this report, we present a mild clinical course of SFTS virus infection in Japan in detail.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Clinical signs of an elderly patient with SFTSV infection. (a) A tick bite was found on the left thigh. (b) Microscopic findings of Giemsa staining of bone marrow showed platelet-specific hemophagocytes. (c) Contrast-enhanced computed tomography showed left inguinal lymphadenopathy alone.
Figure 2
Figure 2
Detection of Japanese SFTSV mRNA using a conventional one-step RT-PCR method. Clinical specimen by RT-PCR: lane 1: our patient's blood sample; lane 2: negative control (NTC); lane 3: positive control (PC) (SFTSV strain HB29 viral RNA). Primer sets numbers 1 and 2 amplified the gene coding SFTSV NP, and the sizes of these products were 458 bp and 461 bp, respectively.

References

    1. Yu X.-J., Liang M.-F., Zhang S.-Y., et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. The New England Journal of Medicine. 2011;364(16):1523–1532. doi: 10.1056/NEJMoa1010095. - DOI - PMC - PubMed
    1. Takahashi T., Maeda K., Suzuki T., et al. The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan. Journal of Infection Disease. 2014;209(6):816–827. - PMC - PubMed
    1. Izukawa K., Miyamura T., Hara S., et al. Mild SFTS case whose clinical differential diagnosis from rickettsiosis was difficult, April 2013. Infectious Agents Surveillance Report. 2013;35:39.
    1. Kaneko T., Wada H. Diagnostic criteria and laboratory tests for disseminated intravascular coagulation. Journal of Clinical and Experimental Hematopathology. 2011;51(2):67–76. doi: 10.3960/jslrt.51.67. - DOI - PubMed
    1. Liu Q., He B., Huang S.-Y., Wei F., Zhu X.-Q. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. The Lancet Infectious Diseases. 2014;14(8):763–772. doi: 10.1016/S1473-3099(14)70718-2. - DOI - PubMed

LinkOut - more resources

Full text links
Wiley full text link Wiley Free PMC article
Cite

AltStyle によって変換されたページ (->オリジナル) /