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. 2014 Dec 31;9(12):e115569.
doi: 10.1371/journal.pone.0115569. eCollection 2014.

Co-circulation of dengue virus type 3 genotypes in Vientiane capital, Lao PDR

Affiliations

Co-circulation of dengue virus type 3 genotypes in Vientiane capital, Lao PDR

Malayvanh Lao et al. PLoS One. .

Abstract

During the 2012 epidemic of dengue in Vientiane capital, Lao PDR, a major serotype switch from dengue 1 to 3 was observed. A molecular epidemiology study demonstrated that dengue 3 remained the predominant serotype in 2013, but also revealed the co-circulation of two genotypes, supporting the hypothesis of multiple geographic origins of dengue 3 strains circulating in Vientiane capital.

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Conflict of interest statement

Competing Interests: All authors declared potential financial competing interest. As specified in the "Funding" section, private companies made free donations to the Institut Pasteur du Laos to support diagnosis and research on dengue during the 2013 epidemic. None of the authors, nor the Institut Pasteur du Laos who received the funds, have or had a contract with these companies. This does not alter all authors' adherence to all PLOS ONE policies on sharing data and materials.

Figures

Figure 1
Figure 1. Surveillance performed by Institut Pasteur du Laos from March 2012 to December 2013.
(A) Distribution of confirmed cases (i.e. RT-PCR and/or NS1 and/or culture positive) in Vientiane city (B). Dengue serotypes distribution in 2012 and 2013. Recording of dengue serotypes distribution on a four monthly basis. As the surveillance only started in late March 2012, partial data collected in April were not included in the figure.
Figure 2
Figure 2. Phylogenetic relationships of DENV-3 based on the complete E nucleotide sequences (1479 nt) of 41 isolates, including 16 Lao isolates.
Blue triangles and blue circles represent Lao DENV-3 genotype II and III strains respectively. Sequence alignments were performed using BioNumerics version 6.6. A maximum-Likelihood tree was constructed using MEGA version 6, based on Tamura-Nei model. Bootstrap resampling values are indicated at major nodes. Scale bar indicates number of base substitutions per site.

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