Snake venom L-amino acid oxidases: an overview on their antitumor effects

doi:10.1186/1678-9199-20-23

Review

. 2014 Jun 2:20:23.

doi: 10.1186/1678-9199-20-23. eCollection 2014.

Snake venom L-amino acid oxidases: an overview on their antitumor effects

Tássia R Costa ¹, Sandra M Burin ¹, Danilo L Menaldo ¹, Fabíola A de Castro ¹, Suely V Sampaio ²

Affiliations

¹ Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil.
² Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil ; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, B. Monte Alegre, Ribeirão Preto, SP CEP 14040-903, Brasil.

PMID: 24940304
PMCID: PMC4060840
DOI: 10.1186/1678-9199-20-23

Review

Snake venom L-amino acid oxidases: an overview on their antitumor effects

Tássia R Costa et al. J Venom Anim Toxins Incl Trop Dis. 2014.

. 2014 Jun 2:20:23.

doi: 10.1186/1678-9199-20-23. eCollection 2014.

Authors

Tássia R Costa ¹, Sandra M Burin ¹, Danilo L Menaldo ¹, Fabíola A de Castro ¹, Suely V Sampaio ²

Affiliations

¹ Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil.
² Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil ; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, B. Monte Alegre, Ribeirão Preto, SP CEP 14040-903, Brasil.

PMID: 24940304
PMCID: PMC4060840
DOI: 10.1186/1678-9199-20-23

Abstract

The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.

Keywords: Antitumor effects; Apoptosis; L-amino acid oxidases; Snake venoms.

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Figures

Figure 1

Figure 1

Representation of the reaction catalyzed by L-amino acid oxidases.

See this image and copyright information in PMC

References

1. Vallon O, Bulté L, Kuras R, Olive J, Wollman FA. Extensive accumulation of an extracellular L-amino acid oxidase during gametogenesis of Chlamydomonas reinhardtii. Eur J Biochem. 1993;215(2):351–360. doi: 10.1111/j.1432-1033.1993.tb18041.x. - DOI - PubMed
1. Du XY, Clemetson KJ. Snake venom L-amino acid oxidases. Toxicon. 2002;40(6):659–665. doi: 10.1016/S0041-0101(02)00102-2. - DOI - PubMed
1. Kamio M, Ko KC, Zheng S, Wang B, Collins SL, Gadda G, Tai PC, Derby CD. The chemistry of escapin: identification and quantification of the components in the complex mixture generated by an L-amino acid oxidase in the defensive secretion of the sea snail Aplysia californica. Chemistry. 2009;15(7):1597–1603. doi: 10.1002/chem.200801696. - DOI - PubMed
1. Chen WM, Sheu FS, Sheu SY. Novel L-amino acid oxidase with algicidal activity against toxic cyanobacterium Microcystis aeruginosa synthesized by a bacterium Aquimarina sp. Enzyme Microb Technol. 2011;49(4):372–379. doi: 10.1016/j.enzmictec.2011年06月01日6. - DOI - PubMed
1. Wang F, Li R, Xie M, Li A. The serum of rabbitfish (Siganus oramin) has antimicrobial activity to some pathogenic organisms and a novel serum L-amino acid oxidase is isolated. Fish Shellfish Immunol. 2011;30(4–5):1095–1108. - PubMed

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[1] Vallon O, Bulté L, Kuras R, Olive J, Wollman FA. Extensive accumulation of an extracellular L-amino acid oxidase during gametogenesis of Chlamydomonas reinhardtii. Eur J Biochem. 1993;215(2):351–360. doi: 10.1111/j.1432-1033.1993.tb18041.x. - DOI - PubMed

[2] Vallon O, Bulté L, Kuras R, Olive J, Wollman FA. Extensive accumulation of an extracellular L-amino acid oxidase during gametogenesis of Chlamydomonas reinhardtii. Eur J Biochem. 1993;215(2):351–360. doi: 10.1111/j.1432-1033.1993.tb18041.x. - DOI - PubMed

[3] Du XY, Clemetson KJ. Snake venom L-amino acid oxidases. Toxicon. 2002;40(6):659–665. doi: 10.1016/S0041-0101(02)00102-2. - DOI - PubMed

[4] Du XY, Clemetson KJ. Snake venom L-amino acid oxidases. Toxicon. 2002;40(6):659–665. doi: 10.1016/S0041-0101(02)00102-2. - DOI - PubMed

[5] Kamio M, Ko KC, Zheng S, Wang B, Collins SL, Gadda G, Tai PC, Derby CD. The chemistry of escapin: identification and quantification of the components in the complex mixture generated by an L-amino acid oxidase in the defensive secretion of the sea snail Aplysia californica. Chemistry. 2009;15(7):1597–1603. doi: 10.1002/chem.200801696. - DOI - PubMed

[6] Kamio M, Ko KC, Zheng S, Wang B, Collins SL, Gadda G, Tai PC, Derby CD. The chemistry of escapin: identification and quantification of the components in the complex mixture generated by an L-amino acid oxidase in the defensive secretion of the sea snail Aplysia californica. Chemistry. 2009;15(7):1597–1603. doi: 10.1002/chem.200801696. - DOI - PubMed

[7] Chen WM, Sheu FS, Sheu SY. Novel L-amino acid oxidase with algicidal activity against toxic cyanobacterium Microcystis aeruginosa synthesized by a bacterium Aquimarina sp. Enzyme Microb Technol. 2011;49(4):372–379. doi: 10.1016/j.enzmictec.2011年06月01日6. - DOI - PubMed

[8] Chen WM, Sheu FS, Sheu SY. Novel L-amino acid oxidase with algicidal activity against toxic cyanobacterium Microcystis aeruginosa synthesized by a bacterium Aquimarina sp. Enzyme Microb Technol. 2011;49(4):372–379. doi: 10.1016/j.enzmictec.2011年06月01日6. - DOI - PubMed

[9] Wang F, Li R, Xie M, Li A. The serum of rabbitfish (Siganus oramin) has antimicrobial activity to some pathogenic organisms and a novel serum L-amino acid oxidase is isolated. Fish Shellfish Immunol. 2011;30(4–5):1095–1108. - PubMed

[10] Wang F, Li R, Xie M, Li A. The serum of rabbitfish (Siganus oramin) has antimicrobial activity to some pathogenic organisms and a novel serum L-amino acid oxidase is isolated. Fish Shellfish Immunol. 2011;30(4–5):1095–1108. - PubMed

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Snake venom L-amino acid oxidases: an overview on their antitumor effects

Affiliations

Snake venom L-amino acid oxidases: an overview on their antitumor effects

Authors

Affiliations

Abstract

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References

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LinkOut - more resources

Full Text Sources

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