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Randomized Controlled Trial
. 2013 Nov;89(5):875-83.
doi: 10.4269/ajtmh.13-0237. Epub 2013 Sep 9.

The impact of a school-based hygiene, water quality and sanitation intervention on soil-transmitted helminth reinfection: a cluster-randomized trial

Affiliations
Randomized Controlled Trial

The impact of a school-based hygiene, water quality and sanitation intervention on soil-transmitted helminth reinfection: a cluster-randomized trial

Matthew C Freeman et al. Am J Trop Med Hyg. 2013 Nov.

Abstract

We conducted a cluster-randomized trial to assess the impact of a school-based water treatment, hygiene, and sanitation program on reducing infection with soil-transmitted helminths (STHs) after school-based deworming. We assessed infection with STHs at baseline and then at two follow-up rounds 8 and 10 months after deworming. Forty government primary schools in Nyanza Province, Kenya were randomly selected and assigned to intervention or control arms. The intervention reduced reinfection prevalence (odds ratio [OR] 0.56, 95% confidence interval [CI] 0.31-1.00) and egg count (rate ratio [RR] 0.34, CI 0.15-0.75) of Ascaris lumbricoides. We found no evidence of significant intervention effects on the overall prevalence and intensity of Trichuris trichiura, hookworm, or Schistosoma mansoni reinfection. Provision of school-based sanitation, water quality, and hygiene improvements may reduce reinfection of STHs after school-based deworming, but the magnitude of the effects may be sex- and helminth species-specific.

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Figures

Figure 1.
Figure 1.
Schools randomly selected for inclusion in the study of helminth reinfection in Nyanza Province, Kenya.
Figure 2.
Figure 2.
Flow diagram of school random selection and allocated as part of cluster-randomized design.

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