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. 2012 Sep;12(9):782-5.
doi: 10.1089/vbz.2011.0928. Epub 2012 Aug 27.

Relationship between Crimean-Congo hemorrhagic fever virus strains circulating in Iran and Turkey: possibilities for transborder transmission

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Relationship between Crimean-Congo hemorrhagic fever virus strains circulating in Iran and Turkey: possibilities for transborder transmission

Mohammadreza Mahzounieh et al. Vector Borne Zoonotic Dis. 2012 Sep.

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is an important zoonotic viral disease that is asymptomatic in infected livestock, but poses a serious threat to humans. The high fatality rate may be due to phylogenetic variations in the virus, transmission routes, and a lack of an efficient surveillance system for the disease. The geographical features of the eastern and southeastern borders of Turkey may facilitate transmission of viruses between countries of the region. Therefore in this study we focused on the genetic relationship between Turkish and Iranian CCHF viruses based on their S-segment sequences. The research was performed on a total of 104 blood samples from small ruminants reared in southwest Iran. The results of phylogenetic analysis showed that Iranian CCHF virus isolates were closely related to human-originating Turkish Group II viruses from a European lineage reported previously.

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Figures

FIG. 1.
FIG. 1.
Map of Iran showing the location of Chaharmahal-va-Bakhtiari province (the black area in southwestern Iran), where the small ruminant samples were collected.
FIG. 2.
FIG. 2.
Phylogenetic analysis of CCHF virus isolates (underlined) from the Chaharmahal-va-Bakhtiari province of southwest Iran. The GeneBank accession numbers for the nucleotide sequences of the CCHF viruses used in the phylogenetic analysis were given in a previous report (Ozkaya et al. 2010). Bootstrap values are given at the nodes of the internal branches. The bar indicates 0.02 nucleotide substitutions per site.

References

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