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. 2011 Jul;85(1):132-7.
doi: 10.4269/ajtmh.2011.10-0482.

Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study

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Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study

Nicolas Senn et al. Am J Trop Med Hyg. 2011 Jul.

Abstract

Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. We performed a prospective age-stratified study in outpatient clinics investigating the prevalence of DF; 578 patients were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither diagnosis. Among the 317 malaria RDT-negative patients, 14% (45/317, 95% CI = 10-18%) had DF. The seroprevalence of dengue immunoglobulin G (IgG) was 83% (204/247, 95% CI = 78-87%), and no dengue hemorrhagic fever was seen. This study provides good evidence for the first time that DF is common in PNG and is responsible for 8% of fever episodes. The common occurrence of DF in a population with presumed previous exposure to dengue is an important observation.

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Figures

Figure 1.
Figure 1.
Classification of acute febrile illness (absolute numbers). RDT = rapid diagnostic test for malaria; BS = blood smear for malaria.
Figure 2.
Figure 2.
Dengue IgG seroprevalence on acute samples; infant (< 1 year) seroprevalences were not shown because of existing maternal circulating antibodies.
Figure 3.
Figure 3.
Distribution across age groups of the prevalence of dengue, malaria, and other diseases in patients presenting with acute febrile illnesses in Madang.

References

    1. Gubler D, Zaki S. In: Pathology of Emerging Infections. Nelson AM, Horsburgh CR, editors. Washington, DC: ASM Press; 1998. (Dengue and other viral hemorrhagic fevers).
    1. World Health Organization . Dengue WHO: Guidelines for the Diagnosis, Treatment, Prevention, and Control. Geneva, Switzerland: World Health Organization; 2009. - PubMed
    1. Deen JL, Harris E, Wills B, Balmaseda A, Hammond SN, Rocha C, Dung NM, Hung NT, Hien TT, Farrar JJ. The WHO dengue classification and case definitions: time for a reassessment. Lancet. 2006;368:170–173. - PubMed
    1. Shibani B, Lucy CSL, Axel K. Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever. Trop Med Int Health. 2006;11:1238–1255. - PubMed
    1. Raymond CSS, Eng Eong O, Hwee Bee W, Nicholas IP. An outbreak of primary dengue infection among migrant Chinese workers in Singapore characterized by prominent gastrointestinal symptoms and a high proportion of symptomatic cases. J Clin Virology. 2005;33:336–340. - PubMed
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