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. 2011 Jan;127(1):279-82, 282.e1-3.
doi: 10.1016/j.jaci.2010年10月02日6.

Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians

Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians

Lucia Elena Alvarado Arnez et al. J Allergy Clin Immunol. 2011 Jan.

Abstract

Variation in the IL4 gene has been associated with parastic infections, but has not been studied in Bolivians infected with Trypanosoma cruzi. Our results suggest that variation at IL4 influences susceptibility to T. cruzi infection in Bolivians.

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Figures

Figure 1
Figure 1
Visual representation of haplotypes at the IL4 locus. Haplotypes are sorted by the derived (Clade A) or ancestral (Clade B) allele at -590C/T (designated by *). Three exonic SNPs are indicated by a "+". White squares correspond to ancestral alleles and black squares to derived alleles. A schematic of the IL4 gene is shown at the bottom of the figure; filled rectangles show exons (drawn to scale).

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