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Review
. 2009 Aug 15;49(4):606-11.
doi: 10.1086/603553.

Invasive non-Typhi Salmonella disease in Africa

Affiliations
Review

Invasive non-Typhi Salmonella disease in Africa

Susan C Morpeth et al. Clin Infect Dis. .

Abstract

Invasive non-Typhi Salmonella is endemic to sub-Saharan Africa, where it is a leading cause of bloodstream infection. Some host risk factors have been established, but little is known about environmental reservoirs and predominant modes of transmission, so prevention strategies are underdeveloped. Although foodborne transmission from animals to humans predominates in high-income countries, it has been postulated that transmission between humans, both within and outside health care facilities, may be important in sub-Saharan Africa. Antimicrobial resistance to ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol is common among non-Typhi Salmonella strains; therefore, wider use of alternative agents may be warranted for empirical therapy. Development of vaccines targeting the leading invasive non-Typhi Salmonella serotypes Typhimurium and Enteritidis is warranted. The clinical presentation of non-Typhi Salmonella bacteremia is nonspecific and, in the absence of blood culture, may be confused with other febrile illnesses, such as malaria. Much work remains to be done to understand and control invasive non-Typhi Salmonella disease in sub-Saharan Africa.

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Conflict of interest statement

Potential conflicts of interest. All authors: no conflicts.

References

    1. Brenner FW, Villar RG, Angulo FJ, Tauxe R, Swaminathan B. Salmonella nomenclature. J Clin Microbiol. 2000;38:2465–7. - PMC - PubMed
    1. Shaw AV, Reddy EA, Crump JA. Etiology of community-acquired bloodstream infections in Africa. Abstract L-620. 46th Annual Meeting of the Infectious Diseases Society of America; Washington, D.C.. 2008.
    1. Graham SM, Molyneux EM, Walsh AL, Cheesbrough JS, Molyneux ME, Hart CA. Nontyphoidal Salmonella infections of children in tropical Africa. Pediatr Infect Dis J. 2000;19:1189–96. - PubMed
    1. Milledge J, Calis JC, Graham SM, et al. Aetiology of neonatal sepsis in Blantyre, Malawi: 1996-2001. Ann Trop Paediatr. 2005;25:101–10. - PubMed
    1. Berkley JA, Lowe BS, Mwangi I, et al. Bacteremia among children admitted to a rural hospital in Kenya. N Engl J Med. 2005;352:39–47. - PubMed

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