This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log in
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2008 Dec;38(14):1663-71.
doi: 10.1016/j.ijpara.2008年05月01日3. Epub 2008 Jun 12.

Relationships between anaemia and parasitic infections in Kenyan schoolchildren: a Bayesian hierarchical modelling approach

Affiliations
Multicenter Study

Relationships between anaemia and parasitic infections in Kenyan schoolchildren: a Bayesian hierarchical modelling approach

Artemis Koukounari et al. Int J Parasitol. 2008 Dec.

Abstract

Anaemia is multi-factorial in origin and disentangling its aetiology remains problematic, with surprisingly few studies investigating the relative contribution of different parasitic infections to anaemia amongst schoolchildren. We report cross-sectional data on haemoglobin, malaria parasitaemia, helminth infection and undernutrition among 1523 schoolchildren enrolled in classes 5 and 6 (aged 10-21 years) in 30 primary schools in western Kenya. Bayesian hierarchical modelling was used to investigate putative relationships. Children infected with Plasmodium falciparum or with a heavy Schistosoma mansoni infection, stunted children and girls were found to have lower haemoglobin concentrations. Children heavily infected with S. mansoni were also more likely to be anaemic compared with uninfected children. This study further highlights the importance of malaria and intestinal schistosomiasis as contributors to reduced haemoglobin levels among schoolchildren and helps guide the implementation of integrated school health programmes in areas of differing parasite transmission.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Box plot of school-level residuals from a Bayesian hierarchical model for Hb counts among older children. Each box plot represents a school-level residual uj in our study. Numbers above each box plot are label identifiers for each school. This is a plot in which the posterior distributions of all ujs are summarised side by side. Boxes represent inter-quartile ranges and the solid black line at the (approximate) centre of each box is the mean of each specific uj; the arms of each box extend to cover the central 95 percent of the distribution–their ends correspond, therefore, to the 2.5% and 97.5% quantiles. The horizontal straight line in the middle of the graph represents the overall mean of the ujs which is set to 0.

References

    1. Beier J.C., Oster C.N., Onyango F.K., Bales J.D., Sherwood J.A., Perkins P.V., Chumo D.K., Koech D.V., Whitmire R.E., Roberts C.R., Diggs C.L., Hoffman S.L. Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya. Am. J. Trop. Med. Hyg. 1994;50:529–536. - PubMed
    1. Brooker S., Peshu N., Warn P.A., Mosobo M., Guyatt H.L., Marsh K., Snow R.W. The epidemiology of hookworm infection and its contribution to anaemia among pre-school children on the Kenyan coast. Trans. R. Soc. Trop. Med. Hyg. 1999;93:240–246. - PubMed
    1. Brooker S., Miguel E.A., Moulin S., Luoba A.I., Bundy D.A., Kremer M. Epidemiology of single and multiple species helminth infections among schoolchildren in Busia district, Kenya. East Afr. Med. J. 2000;78:279–282. - PubMed
    1. Brooker S., Miguel E.A., Waswa P., Namunyu R., Moulin S., Guyatt H., Bundy D.A. The potential of rapid screening methods for Schistosoma mansoni in western Kenya. Ann. Trop. Med. Parasitol. 2001;95:343–351. - PubMed
    1. Brooker S., Akhwale W., Pullan R., Estambale B., Clarke S.E., Snow R.W., Hotez P.J. Epidemiology of Plasmodium-helminth co-infections in Africa: population at risk, potential impact on anaemia and prospects for combined control. Am. J. Trop. Med. Hyg. 2007;77:S88–S98. - PMC - PubMed

Publication types

Full text links
Elsevier Science full text link Elsevier Science Free PMC article
Cite

AltStyle によって変換されたページ (->オリジナル) /