alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprote - Protein

Supplemental Content

Change region shown

Whole sequence
Selected region
from: to:

Customize view

Features added by NCBI

Conserved Domains

Analyze this sequence

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.

Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.

Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...

Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

Show in Genome Data Viewer
Opens the Genome Data Viewer, NCBI's genome browser, at the genomic location at which this sequence is annotated. View this sequence in the context of other features annotated at the same location and browse to other genome regions.

Protein 3D Structure

Structure molecule image The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex

PDB: 7YIX

Source: Homo sapiens

Method: Electron Microscopy

Resolution: 2.96 Å

See all 2 structures...

Articles about the ALPL gene

Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene. [Front Endocrinol (Lausanne). 2...]
Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene.
Martínez-Heredia L, Muñoz-Torres M, Sanabria-de la Torre R, Jiménez-Ortas Á, Andújar-Vera F, González-Cejudo T, Contreras-Bolívar V, González-Salvatierra S, Gómez-Vida JM, García-Fontana C, et al. Front Endocrinol (Lausanne). 2023; 14:1320516. Epub 2024 Jan 3.

Musculoskeletal pain and muscular weakness as the main symptoms of adult hypophosphatasia in a Spanish cohort: clinical characterization and identification of a new ALPL gene variant. [J Bone Miner Metab. 2023]
Musculoskeletal pain and muscular weakness as the main symptoms of adult hypophosphatasia in a Spanish cohort: clinical characterization and identification of a new ALPL gene variant.
Calmarza P, Lapresta C, Martínez García M, Ochoa J, Sienes Bailo P, Acha Pérez J, Beltrán Audera J, González-Roca E. J Bone Miner Metab. 2023 Sep; 41(5):654-665. Epub 2023 Jun 23.

Association between changes in serum alkaline phosphatase levels and radiographic progression in ankylosing spondylitis. [Sci Rep. 2023]
Association between changes in serum alkaline phosphatase levels and radiographic progression in ankylosing spondylitis.
Kim TH, Park SY, Shin JH, Lee S, Joo KB, Koo BS. Sci Rep. 2023 Jun 5; 13(1):9093. Epub 2023 Jun 5.

See all...

Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the ALPL gene (NG_008940.2).

RefSeq mRNA
See reference mRNA sequence for the ALPL gene (NM_000478.6).

More about the ALPL gene

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatase...
Also Known As: AP-TNAP, APTNAP, HOPS, ...

Related information

Nucleotide
Nucleotide sequence from coding region

PubMed
PubMed articles cited by protein sequence record

Taxonomy
Taxonomy sequences associated with protein record

BioAssay by Target (List)
PubChem BioAssays done on the protein target

BioAssay by Target (Summary)
BioAssay by Target (Summary)

CCDS
Link to Consensus CDS

CDD Search Results
Display conserved domains within a protein

Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein

Conserved Domains (Full)
Link to conserved domains within a protein

Domain Relatives
Display proteins with similar conserved domain architecture

Encoding mRNA
Link from protein to encoding mRNA

Full text in PMC
Free full text articles in PMC

Gene
Link to related Genes

Genome
Genome record encoding protein sequence

HomoloGene
Related HomoloGene

Identical Structures
3D structures for identical protein sequences

OMIM
OMIM records associated with protein sequence

Protein (UniProtKB)
Protein gi (refseq) to protein gi (UniProtKB)

PubMed (RefSeq)
Link to RefSeq PubMed articles

PubMed (Weighted)
Links to pubmed

Related Structures (List)
List of related structures

SNP
Related SNPs

LinkOut to external resources

NP_000469 [Domain Mapping of Disease Mut...]
NP_000469
Domain Mapping of Disease Mutations

Ensembl [Ensembl]
Ensembl

GlyGen glycoinformatics resource [GlyGen glycoinformatics resou...]
GlyGen glycoinformatics resource

OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource

Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System

reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

Find Quality Antibodies [GeneTex Inc]
Find Quality Antibodies
GeneTex Inc

Recent activity

Clear Turn Off Turn On

alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein [Homo s...
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein [Homo sapiens]
gi|116734717|ref|NP_000469.3|

Protein

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on
See more...

Help
Finds sub-sequence or patterns in the sequence and highlights the matching region. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences.
More...

Account

Protein

Result Filters

Send to:

alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein [Homo sapiens]

Supplemental Content

Change region shown

Customize view

Features added by NCBI

Analyze this sequence

Protein 3D Structure

Articles about the ALPL gene

Reference sequence information

More about the ALPL gene

Related information

LinkOut to external resources

Recent activity