The relationship of vibriocidal antibody titre to susceptibility to cholera in family contacts of cholera patients*
W H Mosley
Shamsa Ahmad
A S Benenson
Ansaruddin Ahmed
From the Pakistan—SEATO Cholera Research Laboratory, Dacca, East Pakistan. The Pakistan—SEATO Cholera Research Laboratory is a part of the SEATO Cholera Research Program and is supported by the US Department of State, Agency for International Development; the National Institutes of Health (Research Agreement No. 196802), the National Communicable Disease Center, Public Health Service, US Department of Health, Education, and Welfare; and by the Governments of Pakistan and other SEATO nations. The NIH Cholera Advisory Committee co-ordinates the research programme. These studies were supported in part by Research Agreement No. 196802 between the National Institutes of Health, Bethesda, Md., USA, and the Pakistan—SEATO Cholera Research Laboratory, Dacca, East Pakistan.
Abstract
A bacteriological and serological study of family contacts of 81 cholera patients was carried out in Dacca, East Pakistan. In the 10-day follow-up, 78 (16.7%) of 466 contacts were found to be infected with Vibrio cholerae; half of them were symptomatic and 29 had to be admitted to hospital. A study of serum pairs revealed a 4-fold, or greater, rise in titre in 86% of those infected in whom diarrhoea was present, and in 77% of individuals with inapparent infections. The infection rate fell markedly with age. Serological tests for vibriocidal antibody on blood specimens collected at the initiation of the follow-up revealed higher titres with increasing age. Vibrio cholerae infection, whether symptomatic or asymptomatic, predominantly occurred in individuals with low titres.
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Selected References
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