COGs - Clusters of Orthologous Groups

COGs
Phylogenetic classification of proteins encoded in complete genomes

COG links

2024 COGs update [Web interface]
2024 COGs update [FTP]
2020 COGs update [FTP]
2003 COGs, 2014 update [Web interface] (superceded by 2020 update)
2003 COGs, 2014 update [FTP]
2003 COGs, original format [FTP]
2003 KOGs, original format [FTP]
2003 COGs [FTP]
arCOGs [FTP]
NCVOGs [FTP]
mimiCOOGs [FTP]
2013 POGs [FTP]
2011 POGs, annotated [FTP]
2011 POGs, extended [FTP]
COG software [FTP]

Publications

COG database update 2024. Nucleic Acids Res. 2025 Jan 6; D356-D363.
COG database update: focus on microbial diversity, model organisms, and widespread pathogens. Nucleic Acids Res. 2020 Nov 9; gkaa1018.
2019 The COG approach. Brief Bioinform. 2019 Jul 19;20(4):1063-1070.
2017 ATGC-COGs. Nucleic Acids Res. 2017 Jan 4;45(D1):D210-D218.
2014 archaeal COGs. Life 2015 Mar 10;5(1):818-840.
2014 update of 2003 COGs. Nucleic Acids Res. 2015 Jan;43:D261-D269.
mimiCOGs. Virol J. 2013 Apr 4;10:106.
2013 phage COGs. J Bacteriol. 2013 Mar;195(5):941-950.
2012 archaeal COGs. Biol Direct 2012 Dec 14;7:46.
Orthologs and BBH. Genome Biol Evol. 2012 Jan;4(12):1286-1294.
2011 phage COGs. J Bacteriol. 2011 Apr;193(8):1806-1814.
Improved COG algorithm. Bioinformatics 2010 Jun 15;26(12):1481-1487.
NCLDV COGs. Virol J. 2009 Dec 17;6:223.
2007 archaeal COGs. Biol Direct 2007 Nov 27;2:33.
Lactic acid bacteria COGs. Proc Natl Acad Sci U.S.A. 2006 Oct 17;103(42):15611-15616.
Cyanobacterial COGs. Proc Natl Acad Sci U.S.A. 2006 Aug 29;103(35):13126-13131.
2003 eukaryotic KOGs. Genome Biol. 2004 Jan 15;5(2):R7.
2003 database update. BMC Bioinformatics 2003 Sep 11;4(1):41
Original COG paper. Science 1997 Oct 24;278(5338):631-7

Comments and questions to cogs@ncbi.nlm.nih.gov or to the project supervisor.

Updated: February 2025